Nanjing Children's Hospital

Using interpretable machine learning models to predict the occurrence of severe influenza in hospitalized children: a retrospective cohort study

BACKGROUND: Influenza, a prevalent disease, significantly threatens public health. Accurately predicting severe influenza occurrences is crucial for developing personalized prevention strategies and treatment plans. AIMS: This study aimed to construct a highly interpretable model...

Subtotal duodenal resection with tapering duodenoplasty, duodenojejunostomy, and feeding jejunostomy for blind pouch syndrome following congenital duodenal diaphragm repair: a report of two cases

Blind pouch syndrome is a rare late complication following surgery for congenital duodenal diaphragm. Progressive duodenal dilatation and intestinal stasis may result in recurrent vomiting, abdominal distension, feeding intolerance, and malnutrition. We report two paediatric case...

Machine learning for predicting prolonged length of stay among children with infectious mononucleosis

Infectious mononucleosis (IM) is usually self-limited in children but can require a prolonged inpatient course. Prediction of prolonged length of stay (PLOS) from information available at admission may inform the development of future early risk-stratification approaches; however...

Pachymic acid exhibits synergistic antitumor efficacy with lenvatinib in hepatocellular carcinoma by targeting PPARγ to inhibit glycolysis

Lenvatinib is a first-line treatment for hepatocellular carcinoma (HCC), though drug resistance may develop with long-term use. to investigate the potential of pachymic acid to enhance lenvatinib’s anti-tumor efficacy. HepG2 and LM3 cells were exposed to pachymic acid and/or lenv...

A large-scale multi-center analysis reveals that HNRNPA2B1 variants increase neuroblastoma risk in Chinese children

Neuroblastoma has significant clinical heterogeneity, more precise genetic biomarkers are needed for early risk stratification. Although m 6 A modification has been reported to affect tumor development, the epidemiological impact of HNRNPA2B1 polymorphisms on neuroblastoma suscep...

Per- and PolyfluoroalkylSubstances in Pediatric CerebrospinalFluid: Evidence of Central Nervous System Exposure

Abstract Per- and polyfluoroalkyl substances (PFAS) have been implicated in neurodevelopmental toxicity, yet direct evidence of their presence within the central nervous system (CNS) of children remains limited. We quantified 12 PFAS in cerebrospinal fluid (CSF) samples from 47 p...

Subcutaneous Belimumab Demonstrates Consistent Steady-State Pharmacokinetics and is Well Tolerated in Paediatric Patients with SLE in China: An Open-Label Study

This study assessed pharmacokinetics and safety of subcutaneous (SC) belimumab in Chinese paediatric patients with systemic lupus erythematosus (cSLE) who previously received intravenous (IV) belimumab; only the IV form is approved for cSLE in China. This single-arm, open-label,...

Knowledge, attitudes and practice of pediatric nurses on child life therapeutic play: insights into clinical care

Child Life therapeutic play is an evidence-based coping intervention that effectively reduces hospitalization-related distress and promotes cooperation among young patients. However, its routine implementation in clinical settings relies heavily on pediatric nurses’ knowledge, at...