Nanjing Children's Hospital

Per- and PolyfluoroalkylSubstances in Pediatric CerebrospinalFluid: Evidence of Central Nervous System Exposure

Abstract Per- and polyfluoroalkyl substances (PFAS) have been implicated in neurodevelopmental toxicity, yet direct evidence of their presence within the central nervous system (CNS) of children remains limited. We quantified 12 PFAS in cerebrospinal fluid (CSF) samples from 47 p...

Subcutaneous Belimumab Demonstrates Consistent Steady-State Pharmacokinetics and is Well Tolerated in Paediatric Patients with SLE in China: An Open-Label Study

This study assessed pharmacokinetics and safety of subcutaneous (SC) belimumab in Chinese paediatric patients with systemic lupus erythematosus (cSLE) who previously received intravenous (IV) belimumab; only the IV form is approved for cSLE in China. This single-arm, open-label,...

Knowledge, attitudes and practice of pediatric nurses on child life therapeutic play: insights into clinical care

Child Life therapeutic play is an evidence-based coping intervention that effectively reduces hospitalization-related distress and promotes cooperation among young patients. However, its routine implementation in clinical settings relies heavily on pediatric nurses’ knowledge, at...