Nanjing Brain Hospital

Molecular subclassification of MGMT-unmethylated high-grade glioma identifies divergent tumor states and therapeutic vulnerabilities

MGMT-unmethylated high-grade glioma (HGG) is associated with poor response to temozolomide and limited therapeutic options. However, substantial molecular heterogeneity exists within this clinically defined subgroup and remains insufficiently characterized. Transcriptomic and cli...

Complementing Engel Classification: Postoperative Scalp EEG as an Objective Indicator in SEEG ‐Guided Radiofrequency Thermocoagulation—A Seizure‐Onset Pattern‐Based Stratified Analysis—

BACKGROUND: Stereoelectroencephalography-guided radiofrequency thermocoagulation (SEEG-RFTC) is a minimally invasive therapy for drug-resistant focal epilepsy. However, the relationship between specific seizure-onset patterns (SOPs), particularly low-voltage fast activity (LVFA),...

Large language model–assisted scoring of physician-administered parent interviews for autism screening in young children: a retrospective diagnostic case-control and agreement study

Large language models (LLMs) may assist clinicians in scoring narrative parent-report interviews, but diagnostic discrimination, score agreement, output repeatability, and clinical utility are distinct claims. We evaluated an LLM-assisted workflow for scoring a physician-administ...

Intraoperative free-running electromyography as a dynamic adjunct during microvascular decompression for hemifacial spasm

To characterize intraoperative free-running electromyography (EMG) patterns during microvascular decompression (MVD) for hemifacial spasm (HFS) and to evaluate their potential clinical significance, including their distribution across key surgical steps, their utility in distingu...

Gene-brain-behavior links revealing generative neurophysiological subtypes of suicide-related dysconnectivity in bipolar depression

Suicidal thoughts and behaviors (STBs) in bipolar depression are heterogeneous, but biologically coherent subtypes remain poorly defined. We aimed to identify neurophysiological subtypes of suicide-related dysconnectivity in bipolar depression and examine their gene-brain-behavio...

Current status and influencing factors of caring behaviors among nurses in tertiary psychiatric hospitals in China: a cross-sectional study based on latent profile analysis

Mental disorders represent a significant and growing global disease burden. Patients with mental disorders often require prolonged care in closed hospital environments, placing high demands on nurses’ caring behaviors. Although caring behaviors are central to nursing quality and...

Clinical characteristics of thyroid structure and functional abnormalities in bipolar disorder and their association with mood symptoms: a retrospective cross-sectional study

Abstract Background This study aimed to investigate the association between thyroid abnormalities (both structural and functional) and bipolar disorder (BD), and to evaluate the relationship between thyroid parameters and mood symptom severity. Methods In this retrospective cross...

Mechanosensitive epitranscriptomics in cancer: linking tumor mechanics, RNA modification, and immune escape

Solid tumors are mechanically abnormal ecosystems in which extracellular matrix stiffening, compressive stress, interstitial pressure, and aberrant fluid flow reshape cancer, stromal, and immune cell behavior. In parallel, the cancer epitranscriptome has emerged as a dynamic regu...

Association Between Lithium Use and Suicide‐Related Behaviors in Bipolar Disorder: A Multicenter Study

BACKGROUND: Lithium has long been associated with reduced suicide risk in bipolar disorder; however, evidence from real-world clinical populations remains susceptible to confounding, and the behavioral correlates related to this association are not well characterized. METHODS: In...

Insight impairment mediates the effect of SOX2-OT polymorphism on antipsychotic response in first-episode schizophrenia

Insight impairment is a core clinical feature of schizophrenia that predicts poor treatment adherence and unfavorable prognosis. Genetic factors have been increasingly recognized as a likely basis for inter-individual variability in insight; however, direct evidence for a complet...

Temporoparietal structural-functional coupling abnormalities in drug-naïve youths with major depressive disorder and suicidal ideation

Major depressive disorder (MDD) in youth is associated with higher suicide risk. Although white matter and functional connectivity abnormalities have been reported in MDD patients with suicidal ideation (SI), how brain structure and function interact abnormally remains unclear. W...

Clinical Characteristics and Blood-Based Inflammatory Indices of Psychiatric Hospitalizations Among Children with Autism in China: A Retrospective Electronic Medical Records Study

Background/Objectives: This study aimed to investigate the clinical characteristics associated with psychiatric hospitalizations in children with ASD and to evaluate changes in blood-based Inflammatory Indices following treatment. Methods: A retrospective study of 269 children an...

Heatmap-seeded spatially grounded query Transformers improve astrocyte soma detection across Immunostains and scan resolutions

<title>Abstract</title> Background: Automated astrocyte quantification in human immunohistochemistry (IHC) is hindered by stain variability and dense clustering. Standard Transformers often miss faint somata due to agnostic initialization, while CNNs struggle with overlapping pro...

Association between remnant cholesterol inflammatory index and new-onset stroke in different glycemic metabolic states: insights from the China health and retirement longitudinal study

The remnant cholesterol inflammatory index (RCII) has been proposed as a novel biomarker for lipid dysregulation and inflammation, and has also been suggested as a potential risk factor for diabetes. However, the association between RCII and the incidence of new-onset stroke acro...

HearT : Enabling Acoustic Sensing of Ingested-Liquid Temperature via Hydrodynamic Vibration Modeling

Drinking water temperature is linked to gastrointestinal diseases such as gastroesophageal reflux disease, esophageal cancer, and functional dyspepsia. This paper presents HearT , a headphone-deployable system that leverages fluid dynamics–based vibration modeling to infer the te...