Nagoya University Hospital

Olive Oil Before Oral Glucose Delays Gastric Emptying and Lowers Glycemia Through Partially Redundant Glucagon and GLP-1 Signaling in Mice

Consumption of fat before carbohydrate (preload) attenuates postprandial glucose excursions, although the underlying mechanisms remain unclear. We investigated whether an olive oil preload (OG) reduces glycemia by engaging endocrine and neural regulation of gastric emptying. Wild...

Towards responsible AI in workplace-based assessment: a scoping review using Downing’s framework

This scoping review maps generative AI applications in workplace-based assessment (WBA) and analyzes validity evidence through Downing’s framework. Following JBI methodology and PRISMA-ScR guidelines, four databases were searched (2022-February 2026) with dual-AI screening and hu...

Consensus recommendations for neurofibromatosis type 1 management in Asia Pacific

Neurofibromatosis type 1 (NF1) is a complex multisystem disorder requiring coordinated multidisciplinary care. This study aimed to develop consensus recommendations for NF1 management in the Asia-Pacific region. A modified Delphi process involving two survey rounds and a virtual...

Neighborhood interaction at age 65 and subsequent initiation and cessation of social participation in Japanese older adults: the NISSIN Project

Whether neighborhood interaction is differently associated with initiation and cessation of social participation in early old age remains unclear. We analyzed 1,688 Japanese adults surveyed at ages 65 and 70. Initiation and cessation were examined separately using modified Poisso...

Study of Supernova Neutrinos at ESSnuSB

In this paper, we have studied the sensitivity of the ESSnuSB far detector to supernova neutrinos. ESSnuSB is a proposed long-baseline neutrino experiment in Sweden, which will use a 538 kt water Cherenkov detector to probe the leptonic phase δCP by studying the second oscillatio...

The first four ground-level enhancements in the 1940s: investigation, digitization and analysis of forgotten data

Intense solar eruptions occasionally accelerate solar energetic particles (SEPs) and trigger ground-level enhancements (GLEs). Among the 77 known GLEs, the first four #1- 4, in the 1940s, took place before the advent of the standard neutron monitors (NMs) and were missing from th...

Longitudinal hemifield-specific macular ganglion cell complex thinning and its association with arterial stiffness in eyes without baseline glaucomatous abnormalities

PURPOSE: To characterize longitudinal hemifield-specific changes in macular ganglion cell complex (GCC) thickness in eyes without baseline glaucomatous abnormalities and to evaluate whether arterial stiffness, assessed by brachial-ankle pulse wave velocity (baPWV), is associated...

Visualizing electron flow at transition states by natural reaction orbitals

Transition-state analysis in quantum chemistry provides structural and energetic information but does not directly reveal how electron density is redistributed at the onset of bond reorganization. Although frontier-orbital theory is highly effective for predicting reactivity from...

Clinical outcomes before and after the introduction of clazosentan in aneurysmal subarachnoid hemorrhage: a multicenter retrospective study of clipping and endovascular treatment

OBJECTIVE: Definitive treatment for aneurysmal subarachnoid hemorrhage (aSAH) includes microsurgical clipping and endovascular treatment (EVT). In randomized trials such as ISAT and BRAT, EVT showed superiority in short-term outcomes and comparable or favorable long-term results....

Differential Expression of RORγt and T-bet in ALK-Negative Anaplastic Large Cell Lymphoma

ALK-negative anaplastic large cell lymphoma (ALK-negative ALCL) frequently expresses cytotoxic molecules, which may complicate its distinction from peripheral T-cell lymphoma NOS (PTCL-NOS), particularly in cytotoxic molecule-positive cases. Among these, nodal EBV-negative cytoto...

Genomic and clinicopathologic analysis of conventional dendritic cell sarcomas coexisting with myeloid neoplasms

Abstract Langerhans cell sarcoma (LCS), malignant indeterminate dendritic cell tumor (IDCT), and interdigitating dendritic cell sarcoma (IDCS) are rare malignant neoplasms that originate from antigen-presenting conventional dendritic cells (cDCs). These tumors, collectively terme...

Asymmetric defect distribution generates bulk Dzyaloshinskii–Moriya interaction in Pt/Co/Pt

The Dzyaloshinskii–Moriya interaction (DMI) in magnetic multilayers plays a pivotal role in spintronic applications by enabling the stabilization and manipulation of chiral spin textures, including chiral domain walls and skyrmions. While interfacial DMI in asymmetric multilayers...

Fracture laterality as an independent prognostic factor for clinical outcomes after hip fracture surgery

Aims Fracture laterality is routinely recorded in large hip fracture registries for administrative purposes, yet rarely evaluated as a prognostic variable. We aimed to test whether laterality is independently associated with short-term outcomes after hip fracture surgery. Methods...

Exploring Patient Needs and Respective Contributing Factors Regarding Hospital and Community Pharmacists for Outpatients with Cancer

Improving the quality and safety of outpatient chemotherapy requires effective information sharing between hospitals and community pharmacies. However, achieving truly patient-centered care necessitates pharmacists to go beyond information exchange and develop a deeper understand...

Plasticity of extrachromosomal DNA segregation during drug adaptation

Uneven segregation during mitosis is a striking feature of extrachromosomal DNA (ecDNA). Because ecDNA lacks a centromere, it is thought to segregate stochastically, generating intratumoral heterogeneity in genomic copy number. Drug treatment can readily change ecDNA copy number,...