Nagoya Medical Center

Durable disease control following multidisciplinary treatment including pembrolizumab in POLE-mutated dedifferentiated endometrial carcinoma with brain metastases

Rationale: Dedifferentiated endometrial carcinoma (DEC) is a rare and aggressive subtype of endometrial cancer comprising undifferentiated carcinoma and a low-grade endometrioid component. Although POLE -mutated tumors usually show favorable outcomes owing to their ultramutated a...

Association Between Acute-Phase Occupational Therapy and Quality of Life at Hospital Discharge and 90 Days After Discharge

Background/Objectives: Early rehabilitation in critically ill patients has been associated with improved physical outcomes. However, evidence regarding the association between occupational therapy and quality of life (QOL) remains limited. This study examined the association betw...

Genomic and clinicopathologic analysis of conventional dendritic cell sarcomas coexisting with myeloid neoplasms

Abstract Langerhans cell sarcoma (LCS), malignant indeterminate dendritic cell tumor (IDCT), and interdigitating dendritic cell sarcoma (IDCS) are rare malignant neoplasms that originate from antigen-presenting conventional dendritic cells (cDCs). These tumors, collectively terme...

Pneumonitis in Older Patients With Non-squamous Non-small Cell Lung Cancer Treated With Pembrolizumab and Pemetrexed

Background/Aim: Pembrolizumab combined with pemetrexed is efficacious in older patients with metastatic non-squamous non-small cell lung cancer (NSCLC) and a PD-L1 tumor proportion score (TPS) of <50%. However, treatment-related pneumonitis is concerning, and its impact on clinic...

Sex-based survival differences in patients with untreated advanced oesophageal squamous cell carcinoma receiving chemotherapy and immune checkpoint inhibitors: a meta-analysis

Purpose Chemotherapy combined with immune checkpoint inhibitors (ICIs) is the standard first-line treatment for patients with advanced oesophageal squamous cell carcinoma (OSCC). Evidence from other tumour types suggests that biological sex may influence ICI efficacy, but this re...

Association of medical visit frequency with cardiovascular events and mortality in patients with dyslipidaemia: a cohort study using a Japanese claims database

Abstract Background Dyslipidaemia is a major risk factor for cardiovascular and cerebrovascular diseases; however, the optimal frequency of medical visits remains unclear. Objective To examine whether medical visit frequency is associated with the incidence of cardiac events, cer...