Nagasaki University Hospital

Central Retinal Artery–Oriented Embolization of Periorbital Arteriovenous Malformations: Distal Ophthalmic Artery Coil Protection Enabling Aggressive Nidus Treatment

BACKGROUND AND PURPOSE: Periorbital AVMs are frequently supplied by the ophthalmic artery. Its branch, the central retinal artery, has no effective collateral supply; inadvertent embolization may therefore cause irreversible blindness. Because vision loss has been reported after...

Association Between Acute-Phase Occupational Therapy and Quality of Life at Hospital Discharge and 90 Days After Discharge

Background/Objectives: Early rehabilitation in critically ill patients has been associated with improved physical outcomes. However, evidence regarding the association between occupational therapy and quality of life (QOL) remains limited. This study examined the association betw...

Divergent proviral load trajectories and clonal dynamics of HTLV-1-infected cells during antirheumatic therapy in rheumatoid arthritis

The optimal management of human T-cell leukemia virus type 1 (HTLV-1) carriers requiring long-term immunomodulatory therapy remains unclear. Patients with rheumatoid arthritis (RA) living with HTLV-1 frequently receive antirheumatic therapy, raising concerns regarding the potenti...

Respiratory Support With Nasal High Flow Reduces Opioid Requirements During Endoscopic Retrograde Cholangiopancreatography

ABSTRACT Objectives Nasal high flow (NHF) improves oxygenation, reduces the work of breathing, and stabilizes ventilation. In endoscopic retrograde cholangiopancreatography (ERCP) under dexmedetomidine‐based sedation, opioids are often required but increase the risk of respirator...

Cardiac Manifestations Following Suspected Cobra ( Naja samarensis ) Bites in Eastern Visayas, Philippines: A Case Series

Naja samarensis , a World Health Organization Category 1 venomous snake endemic to the Philippines, causes neurotoxic envenomation, but cardiac complications are rarely documented. Case 1 is a 71-y-old hypertensive male who presented with altered consciousness, ptosis, and dysart...

Factors Affecting Postoperative Delirium in Patients With Colorectal Cancer

Background/Aim: As the population ages, the number of patients with colorectal cancer (CRC) is increasing. It is also said that older adults are at higher risk of delirium. The aim of this study was to investigate risk factors for delirium after CRC surgery, and its impact on per...

Latent space structure of retinal age: an artificial intelligence–based analysis of aging in fundus images

Abstract This study investigated whether age-related variation is organized as a geometric structure in latent space and how fine-tuning reshapes this representation. Fundus photographs from fellow eyes of patients who underwent macular surgery were retrospectively analyzed. Afte...

Altered kinematics and muscle activities during half squats in people with ankle sprain history

Abstract Regardless of the high recurrence rate, copers manage the damage after a sprain. Copers do not experience ankle instability and continue their daily activities. However, it is unclear whether copers can use movement strategies similar to people without an ankle sprain. I...

Relationship between initial dose, dose intensity, and survival in unresectable pancreatic cancer treated with nanoliposomal irinotecan, fluorouracil, and folinic acid

Abstract While nanoliposomal irinotecan with fluorouracil and folinic acid (NFF) is a standard second-line regimen for unresectable pancreatic cancer (uPC) after gemcitabine-based therapy, the effects of initial dosing and relative dose intensity (RDI) in routine practice are unc...

Rheumatoid arthritis-associated peptidylarginine deiminase 4 haplotype citrullinates human immunodeficiency virus-pol and confers antiviral activity

Peptidylarginine deiminase 4 (PADI4)-mediated citrullination modulates immune responses and drives autoantibody formation in rheumatoid arthritis (RA). Two common haplotypes, defined by four exonic SNPs ( PADI4_89 , 90 , 92 , and 104 ), have been described, with haplotype 2 (the...