N2 Biomedical (United States)

The amyloid plaque proteomes of Alzheimer’s disease and mild cognitive impairment

Amyloid plaques contain numerous proteins in addition to amyloid beta in Alzheimer’s disease (AD). Previous localized proteomics identified plaque-associated proteins in late-onset AD, early-onset AD, rapidly progressive AD, preclinical AD, and AD in Down syndrome, although most...