Museum of Japanese Art Yamato Bunkakan

A multicenter phase II trial of ramucirumab plus irinotecan for early recurrence of gastric cancer during or after adjuvant chemotherapy with docetaxel plus S-1 therapy: the RAMIEL trial (OGSG1901)

Abstract Background There is currently no established chemotherapy regimen for early recurrence of pathological stage III gastric cancer (GC) following adjuvant chemotherapy with docetaxel plus S-1 (DS) after D2 gastrectomy. We aimed to evaluate the efficacy and safety of ramucir...

Impact of Inhibitor Size and Flexibility on the Binding Pathways to c-Src Kinase

Abstract The conformational plasticity of protein kinases poses a challenge for inhibitor design, motivating the use of molecular dynamics (MD) simulations to study their dynamic binding processes. While conformational changes are increasingly discussed, the impact of drug compou...

Mining of NovelHuman DPP-IV-Targeting Tripeptidesthrough Multicomputational Screening and In Vitro Validation for DiabetesTherapy

Abstract Inhibition of human dipeptidyl peptidase IV (hDPP-IV) is considered an effective strategy in the management of type 2 diabetes (T2D). However, the lack of high-throughput screening approaches and the high cost of experimental evaluation have limited the discovery of pept...

Building a Physics-Aware AI Ecosystem for Solid-State Hydrogen Storage Materials

Abstract Hydrogen storage remains a central bottleneck for scalable hydrogen energy systems due to the multiscale and coupled nature of the thermodynamics, kinetics, and microstructural evolution of hydrogen storage materials (HSMs). Although artificial intelligence (AI) has acce...

Psychological profiles of readiness for advance care planning in super-aged Japan

Advance care planning (ACP) helps ensure that future medical care reflects individuals’ values and preferences. However, little is known about how multiple psychological characteristics combine to shape readiness for ACP, particularly in Japan. This study aimed to identify psycho...

Spatio-Temporal Behavior of End-Wall Film Cooling of a Turbine Vane with Purge Flow Measured by Fast-Response Pressure-Sensitive Paint

Abstract The demand for high-efficiency, low-emission gas turbines has intensified with growing global energy consumption. In modern turbines, elevated inlet temperatures and uniform combustor-exit profiles expose the first-stage vane endwall to severe thermal loads. Complex vort...