Muscular Dystrophy Association

Optimizing Immunohistochemical Detection of Matriglycan in Muscles of Dystroglycanopathy

Detection of matriglycan on α-dystroglycan by immunohistochemistry is one of the essential approaches for studying the mechanisms of functional glycosylation of α-DG, the pathogenesis of dystroglycanopathy, and developing experimental therapies. The limited source of matriglycan-...

Ribitoborate Synergism with Histone Deacetylase Inhibitor Romidepsin as a Potential Treatment for Breast Cancer

Triple-negative breast cancer (TNBC) is a subtype associated with poor prognosis and low survival rates, largely due to limited treatment options. In recent years, histone deacetylase (HDAC) inhibitors have emerged as promising anti-cancer candidates due to their attractive epige...

Xylose phosphatase activity of dystroglycan self-regulates its receptor function

Dystroglycan (DG), a transmembrane receptor crucial for tissue development and pathogen entry, harbors a glycan composed of xylose and glucuronic acid called matriglycan. Loss of matriglycan or reduction in its length affects DG function, causing dystroglycanopathies. However, th...