MUSC Hollings Cancer Center

Nicotine replacement therapy sampling for cigarette cessation in dental care: A National Dental Practice‐Based Research Network cluster randomized clinical trial

BACKGROUND AND AIMS: Cigarette smoking is detrimental to oral health. Oral health professionals rarely prescribe smoking cessation medications. Nicotine replacement therapy sampling (NRTS), providing brief starter courses of NRT, could improve provision of NRT and promote cessati...

Ferroptosis in liver biology and diseases.

Ferroptosis is a form of non-apoptotic cell death driven by iron-dependent lipid peroxidation (LPO). Ferroptosis is closely associated with hepatic metabolic pathways, particularly those involving iron, fatty acids, amino acids, and redox changes. This review aims to provide a co...

DNA Methylation Patterns Between Serous Uterine and Ovarian Carcinomas Indicate Shared Markers with Fallopian Tube Epithelium and Distinctions Consistent with Histopathology

Background/Objectives: Uterine serous carcinoma (USC) is a deadly form of Type II endometrial cancer of rising incidence in the USA. It is currently thought to originate in the uterus, but emerging evidence suggests USC etiology is more complex and may involve the fallopian tube....

HPV-associated Cancer Diagnoses and Mortality in People With HIV in South Carolina During the Antiretroviral Therapy Era

Objectives: We aimed to determine whether people with HIV (PWH) and HPV-associated cancers (HACs) were more likely to be diagnosed at younger ages, at more advanced stages, and have increased mortality. Methods: This is a retrospective cohort study of people diagnosed with HACs i...

Summary of Research: Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma

This is a summary of the original research article “Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma.” The phase 2 SGN35-027 study (NCT03646123) is a multiple-part clinical trial of brentuximab vedotin (BV), w...

A Clinically Aligned 18-Item Instrument for Measuring Inflammatory Breast Cancer Knowledge

This survey study evaluates preliminary, clinically informed exploratory indices to evaluate inflammatory breast cancer knowledge, including symptom and risk-factor recognition.

Stereotactic Body Radiotherapy vs Moderately Hypofractionated IMRT for Localized Intermediate-Risk Prostate Cancer

Importance The treatment of prostate cancer with radiotherapy is evolving. How quickly radiotherapy can be delivered, and the relative risks and benefits of such a treatment, is of significant public interest. Objective To determine whether stereotactic body radiotherapy (SBRT) w...

RAS inhibition limits oncogenic signaling and tumorigenesis in neuroblastoma regardless of RAS mutational status

Abstract Neuroblastoma (NBL) is a rare and aggressive pediatric malignancy with a 5-year survival rate of 40–50% for patients diagnosed with high-risk disease. NBLs arise in the sympathetic nervous system and causes 11% of all pediatric cancer deaths. MYCN amplification or overex...