Municipal Institute for Medical Research

Irreversible electroporation for liver metastases not amenable to conventional treatments, an experience with technical challenges, clinical outcomes, and complications

Irreversible electroporation (IRE) is a non-thermal ablation technique for perivascular liver tumors unsuitable for conventional thermal ablation due to heat-sink effects. This prospective, single-center, single-arm study (2020–2025) evaluated IRE in 14 patients with 16 anatomica...

Targeting food addiction through an intensive energy-reduced Mediterranean diet lifestyle intervention: evidence from the 3-year PREDIMED-plus trial

Food addiction (FA) has been proposed as a behavioural phenotype linked to obesity, potentially influencing adherence and response to lifestyle interventions. Its role within long-term, multicomponent weight-loss programmes remains unclear. This study evaluated the impact of an i...

A cluster-randomized controlled trial of a family-based psychosocial intervention to prevent childhood obesity from preschool ages: the PRESAFALIN study protocol

Abstract Background: Childhood obesity is a major global concern, and Spain's high obesity rates highlight the urgent need for effective and innovative interventions in early age. The PRESAFALIN study aims to promote parental competence, self-efficacy, and resilience to improve c...

A serotonergic mechanism is involved in the pro-cognitive effect of AM6545 treatment in a mouse model of fragile X syndrome

Abstract Fragile X syndrome (FXS) is the principal monogenic syndrome leading to inherited intellectual disability and autism. It is caused by the silencing of FMR1 gene that leads to the loss in the expression of its encoded protein, the fragile X messenger ribonucleoprotein 1 (...

The first 72 hours of acute pancreatitis: patterns of variability in early clinical decision-making

To assess real-world adherence to evidence-based international guidelines in the early management of acute pancreatitis (AP), and to identify how variability in clinical decision-making is distributed during the first 72 h of care. This multicentre, cross-sectional survey was con...