Municipal Institute for Medical Research

A serotonergic mechanism is involved in the pro-cognitive effect of AM6545 treatment in a mouse model of fragile X syndrome

Abstract Fragile X syndrome (FXS) is the principal monogenic syndrome leading to inherited intellectual disability and autism. It is caused by the silencing of FMR1 gene that leads to the loss in the expression of its encoded protein, the fragile X messenger ribonucleoprotein 1 (...

The first 72 hours of acute pancreatitis: patterns of variability in early clinical decision-making

To assess real-world adherence to evidence-based international guidelines in the early management of acute pancreatitis (AP), and to identify how variability in clinical decision-making is distributed during the first 72 h of care. This multicentre, cross-sectional survey was con...