MultiMedica

Impaired Flow and Physiology in Coronaries With Anomalous Origin From the Opposite Sinus of Valsalva

BACKGROUND: Anomalous Aortic Origin of a Coronary Artery (AAOCA) high-risk anatomical features (intramural segment, acute take-off angle, slit-like ostium) cause coronary stenosis leading to myocardial infarction. How these features alter coronary physiology remains unclear. AIMS...

VEGF pathway signalling across pulmonary neuroendocrine tumours: associations with histological subtypes in a multicentre study

Abstract The current classification of pulmonary neuroendocrine neoplasms (NENs) is primarily based on histomorphological criteria, which do not fully capture their underlying biological heterogeneity. This limitation is particularly evident among pulmonary carcinoids, a subgroup...

Machine learning-guided screening of urine cultures for urinary tract infection diagnosis according to AMCLI guidelines

Urinary tract infections (UTIs) are among the most prevalent bacterial infections, and their diagnosis relies on the accurate interpretation of urine cultures. However, manual evaluation is time-consuming, operator-dependent, and susceptible to diagnostic variability. In this stu...

Persistent Post-Burn Pruritus Following Antihistamine Initiation: A Retrospective Longitudinal Study at a Single Italian Pediatric Burn Center

Background/Objectives: An operationally defined unchanged itch-score sequence may indicate persistent symptoms rather than symptom resolution. We described pruritus following antihistamine initiation in children with burns and examined how its apparent stabilization depended on t...

Self-care–based clinical and metabolic profiles among adults with type 2 diabetes: a cross-sectional cluster analysis

Type 2 diabetes mellitus is a heterogeneous condition influenced by clinical, metabolic, and behavioral factors. Traditional approaches to diabetes management often rely on single clinical indicators and may overlook meaningful patterns in patients’ self-care behaviors. This stud...

CT-derived myocardial extracellular volume: current evidence, clinical utility, and the emerging role of photon-counting CT—a systematic review

Abstract Objective Cardiac extracellular volume (ECV) is a quantitative imaging biomarker of myocardial interstitial expansion and diffuse fibrosis, with cardiac magnetic resonance regarded as the reference standard method for assessment. Interest in computed tomography (CT)-deri...

Assessing glymphatic role in the association between choroid plexus enlargement and white matter lesions load: The uncertain path through diffusion tensor imaging along the perivascular space (DTI-ALPS)

Background The choroid plexus (CP) is involved in cerebrospinal fluid production, immune surveillance, and brain fluid homeostasis. CP enlargement has been linked to neuroinflammation, glymphatic dysfunction, and white matter lesion (WML) burden, but the mechanisms underlying the...

Effectiveness of Therapeutic Sport Footwear in Prevention of Ulcer Recurrence in Persons with Diabetic Foot Disease

Recurrence of diabetic foot ulcer (DFU) remains a major clinical challenge in patients with diabetes. Therapeutic footwear is a cornerstone of secondary prevention as it reduces plantar pressure and mechanical stress. However, most available evidence focuses on traditional orthop...