MSH Medical School Hamburg – University of Applied Sciences and Medical University

A GPRC5B–Fyn signaling axis regulates VRAC activity by targeting LRRC8A

The mechanisms by which physiological signals gate the volume-regulated anion channel (VRAC) remain poorly understood. Here, we identify a GPRC5B–Fyn signaling axis that directly controls VRAC activation by targeting the essential subunit LRRC8A. We found that the orphan G protei...

Synthesis, Cytotoxicity, and Mechanistic Evaluation of Thiazolium-Based Gold(I) Bis- N -Heterocyclic Carbene Complexes

Abstract Imidazole- and benzimidazole-based Au(I) N-heterocyclic carbene (NHC) complexes show great potency as anticancer agents. However, other NHC scaffolds are only sparsely explored. Four gold(I) NHC complexes featuring thiazolium-based ligands (NHCthia) with varying N-substi...

Intracranial rescue stenting in the German stroke registry: a propensity score-matched multicenter study

Abstract Background Intracranial stenting (ICS) is used as a rescue strategy in patients with failed reperfusion after endovascular thrombectomy (EVT). However, real-world data on clinical outcomes and safety remain limited. Methods This retrospective analysis of prospectively co...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Barriers and facilitators of mental health app use among young women – a multimethod study

Abstract Background Prevalences of psychological distress among young women are high and rising. Despite a vast number of potentially helpful mental health apps (MHA), dissemination is limited. The current study aims to inform user-centered development and implementation of menta...

Prophylactic vs Therapeutic Anticoagulation in Hospitalized Patients With COVID-19

Importance Coagulopathy in the context of COVID-19 is a major threat due to deep vein thromboses and pulmonary embolisms. Objective To assess whether therapeutic anticoagulation on top of standard of care (SOC) compared with prophylactic anticoagulation as part of SOC can improve...

The intracellular subdomain of the volume-regulated anion channel subunit LRRC8A is a hotspot of channel activation

Abstract Volume-regulated anion channels (VRACs), formed by heteromers of LRRC8 subunits, mediate the transport of anions and organic osmolytes in numerous physiological processes. Although their gating mechanism remains poorly understood, conformational rearrangements of the cyt...

The impact of patients suicide on the mental health of psychotherapists

Abstract A great number of psychotherapists and psychiatrists experience at least one patient suicide during their career. This study aims to build upon previous research findings concerning the impact of experienced patient suicide on the mental health of practicing and trainee...

The Molecular Architecture of Somatic Spines of the Lateral Septum

ABSTRACT The lateral septum is a key subcortical structure and has been implicated in social memory. One aspect of social memory, the ability to recognize relatives, is conserved across vertebrate species and reflected in stable, lifelong memories. Synapses are considered to be t...

Prediction of Treatment Benefit With Internet-Based Cognitive Behavioral Therapy for Depression

Importance Treatment benefit prediction models may help identify which patients will benefit most from internet-based cognitive behavioral therapy (iCBT) for depression; it is unclear whether such models can support useful treatment allocation across programs. Objective To develo...

Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness

Abstract Many bipolar disorder (BD) patients are non-responsive to lithium. The mechanisms underlying lithium (non-)responsiveness are largely unknown. By using gene-set enrichment analysis methods, we found that core clock gene-sets are significantly associated with lithium resp...

CMR-based aortic stiffness parameters in a symptomatic high risk obstructive sleep apnea cohort: results from the population-based Hamburg City Health Study

Abstract Background Aortic stiffness (AS) parameters as pulse wave velocity (PWV), aortic distensibility of the ascending and descending aorta (AD AoAsc, AD AoDesc) and pulse pressure (PP) are marker for vascular ageing, whereas data concerning obstructive sleep apnea (OSA) in po...

Development and validation of a self-report questionnaire to assess executive functions in healthy adults: the executive functions in healthy adults questionnaire (EFHAQ)

Abstract Aim of this research was to develop and validate a time-efficient, ecologically valid self-report questionnaire measuring executive functions in healthy adults, grounded in the unity/diversity framework of Miyake (i.e., inhibition, updating, shifting). Across a pre-study...