MSB Medical School Berlin

Emotion regulation in compulsive sexual behavior disorder: Divergence between self-report and neural measures

Background With Compulsive Sexual Behavior Disorder (CSBD) forming a new category in the ICD-11, a discussion arose as to whether deficits in emotion regulation are part of the symptoms. Aims This study aims to further our knowledge on emotion regulation in CSBD by comparing a cl...

SEMi-Complete by Design: A Monte Carlo simulation to assess Measurement Invariance in Moderated Nonlinear Factor Analysis and SEM-Trees

Ensuring the validity of psychological assessments is crucial, yet differential itemfunctioning (DIF) can threaten measurement invariance (MI) (Bauer, Belzak, and Cole2020). Recent calls for improved DIF detection methods emphasize the need for moreadvanced statistical approaches...

Redesigning Teaching, Learning, and Assessment in the Age of Generative AI: A Constructive Alignment Perspective for Higher Education

Generative artificial intelligence (GenAI) has changed the conditions under which students in higher education read, write, solve problems, and complete assessed work. The central pedagogical question is therefore no longer whether students use AI, but how AI use reshapes the rel...

The Proteinase Activated Receptor-2 mediates Protective Immunity in Early Experimental Leishmaniasis

Resistance to Leishmania (L.) major depends on the development of a L. major-specific Th1 response, while Th2 differentiation results in susceptibility. We previously showed that the early microenvironment of infected skin delivers important signals for T cell differentiation. We...

Ketamine’s impact on rumination-related brain dynamics: insights from a randomized controlled fMRI trial

Abstract Rumination has been associated with aberrant dynamics of a coactivation pattern (CAP) comprising the default mode (DMN) and frontoparietal (FPN) networks. Ketamine exerts rapid antidepressant effects and may influence these dynamics via glutamatergic mechanisms. In a ran...

Evaluating clinical and neuroimaging predictors for cognitive-behavioral therapy outcome in obsessive-compulsive disorder

Abstract Cognitive-behavioral therapy (CBT) is the first-line treatment for obsessive-compulsive disorder (OCD), yet a significant number of patients do not achieve remission or substantial symptom relief. This study aims to enhance the prediction of CBT outcomes in OCD by integr...