MRC/UVRI & LSHTM Uganda Research Unit

Temporal organization of the Plasmodium falciparum transcriptome prioritises genetic polymorphisms associated with artemisinin response

Abstract Artemisinin-based combination therapies (ACTs) have substantially reduced the global burden of malaria, but the emergence and spread of artemisinin partial resistance (ART-R) threatens these gains. Although mutations in Plasmodium falciparum kelch13 (pfk13) are establish...

Adjusting for medication status in genome-wide association studies

Abstract When conducting genome-wide association studies, addressing medication status that is relevant to the trait of interest can prevent biases that could distort estimates of the true genetic effect. Here, we introduce the genetic empirical medication reduction adjustment (G...