MRC Weatherall Institute of Molecular Medicine

Human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis

Microglia are the primary immune cells of the brain, but their role in Parkinson’s disease is not fully understood. Chronic microglial activation is toxic to neurons, but in the early stages of pathology, microglia also exert beneficial functions. We used induced pluripotent stem...

Retrotransposable element derepression distinguishes DNMT3A-mutant from TET2-mutant clonal haematopoiesis

Clonal haematopoiesis (CH) is driven by somatic mutations in haematopoietic stem cells that generate clonal populations detectable in peripheral blood and is present in 10-20% of individuals over the age of 65. Mutations in DNMT3A and TET2 are the most common drivers and have bee...

Molecular-level observation of the self-assembly of a virus-like particle

Abstract Biomolecular assembly is a cornerstone of cellular organization. Revealing its underlying principles is essential for understanding biological function 1,2 and malfunction in disease 3,4 . Viral capsid assembly is the archetypal self-assembly system 5–7 , which has been...

Machine learning provides individualized prediction of outcomes after first complete remission without allo‐HSCT consolidation in adult acute myeloid leukemia—A HARMONY study

Abstract Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a curative treatment option for a significant proportion of patients with acute myeloid leukemia (AML), and it is generally recommended when the relapse risk without allo‐HSCT outweighs the estimated non‐r...