MRC Unit the Gambia

Characterising recent antimalarial resistance in West Africa: Insights from amplicon sequencing of 17,384 Plasmodium falciparum infection samples

<ns5:p> Background <ns5:italic>Plasmodium falciparum</ns5:italic> ( <ns5:italic>P. falciparum</ns5:italic> ) infection remains a significant public health threat in West Africa, where chemoprevention and first-line therapies are key interventions against malaria. However, the dev...

Prevotella stercorea links gut microbiome ecology to respiratory infection protection through host-context-dependent, richness-independent associations

Using a longitudinal cohort of 633 Gambian children (IHAT-GUT, NCT02941081), we investigated two ecologically distinct pathways potentially linking Prevotella stercorea abundance to infection risk: a community-mediated pathway operating through overall gut microbiome richness, an...

Participant attrition in a multi-regional population-based study in Africa: insights from the AWI-Gen study

Attrition in longitudinal studies, defined as the loss of participants over time, may threaten the validity of study results. This study examined patterns, magnitude, and risk factors for attrition in the AWI-Gen cohort. The study included 12,032 participants from six African sit...