MRC Mitochondrial Biology Unit

Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species

Reactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes. Emerging data suggest that T cells depend on ROS for signal transduction. In this study, we show...

Maternal DNA repair safeguards genome stability during the oocyte-to-embryo transition

Abstract De novo mutations are a major source of genetic variation and disease risk, yet the developmental timing and mechanisms underlying their origin require further investigation. While germ cells have traditionally been considered the primary source of these mutations, incre...