MRC Metabolic Diseases Unit

Data-driven identification of small molecules inducing brown adipocyte activation and differentiation

Promoting the recruitment and function of human brown adipose tissue (BAT) holds significant promise for preventing and treating obesity and related metabolic complications. While identifying genes to enhance BAT recruitment and thermogenic activation is crucial, traditional upre...

Rapid Whole Genome Sequencing Enhances Pediatric Cancer Diagnosis

Abstract Whole-genome sequencing (WGS) has been shown to improve diagnosis beyond standard-of-care genetic tests and guide precision treatment for childhood cancer. While WGS is now offered for children with suspected cancer in England, clinical workflows typically return results...