MRC Laboratory for Molecular Cell Biology

A new megaraptoran dinosaur from the Lower Cretaceous Wessex Formation, UK, and its implications for theropod evolution and biogeography

Abstract Theropod dinosaur remains from the Barremian (Lower Cretaceous) Wessex Formation of the Isle of Wight, UK, are rare and often fragmentary. Here, we present a previously undescribed braincase from this formation that represents a new coelurosaurian, Invictibellatrix amber...

High-content image-based screening reveals vaccinia virus membrane proteins as potential regulators of LC3 lipidation

Autophagy is a catabolic process used for the degradation of organelles and proteins, and it also functions as a cellular defense mechanism, known as xenophagy, during infection. Vaccinia virus (VACV), the prototypic poxvirus, replicates exclusively in the cytoplasm of host cells...

ReScale4DL: balancing pixel and contextual information for enhanced bioimage segmentation

Abstract Deep learning is the state-of-the-art approach for bioimage segmentation. However, it presents a paradox regarding image resolution: counterintuitively, deep learning segmentation performance can improve with lower image resolutions. This phenomenon is particularly signi...

Pho84/GLUT2 are cellular myo-inositol exporters regulated by inositol pyrophosphates

Abstract Inositol is an essential nutrient for most living organisms, as combinatorial phosphorylation on this cyclic sugar generates key cellular messengers, such as lipid-bound phosphoinositides (PtdInsPs), water-soluble inositol phosphates (InsPs), and high-energy inositol pyr...