MRC Clinical Trials Unit at UCL

Can discussions with patients and the public clarify missing data mechanisms for digital outcome measures?

Abstract Background Analysis of clinical trials with missing data requires statistical assumptions. When novel digital outcome measures are used, it is particularly important to understand trial participants’ experiences with the device. This can illuminate the reasons for and sp...

Introduction to Trial‐Level Subgroup Analysis: A Tutorial

ABSTRACT This tutorial introduces the concept of trial‐level subgroup analysis in meta‐analysis. We describe the rationale for conducting subgroup analyses, distinguish trial‐level from participant‐level characteristics, outline how to properly interpret effects within subgroups,...

Exploring Heterogeneity in Meta‐Analysis Using Trial‐Level Characteristics: A Tutorial

ABSTRACT This tutorial describes how to explore across‐trial heterogeneity in meta‐analysis using trial‐level characteristics. It describes how to carry out a subgroup analysis for a trial‐level characteristic with more than two categories and provides approaches for analysing co...