MRC Centre for Neurodevelopmental Disorders

A preconceptional stress model identifies thalamostriatal substrates of intergenerational vulnerability

Abstract Antenatal depression affects up to 20% of pregnancies worldwide and is associated with increased neuropsychiatric vulnerability in offspring, yet the enduring behavioural, neuroanatomical, and molecular features associated with maternal mood disturbance remain incomplete...

The purinergic receptor P2Y 13 controls the activation and mode of division of adult ventricular–subventricular zone neural stem cells

ABSTRACT The subependymal zone (SEZ) of the mammalian brain is the most active germinal area that continues to generate newborn neurons throughout life. This area harbors a population of neural stem cells (NSCs) that can be found in different states of activation, each differing...

Autistic neural ‘shiftability’: the distinct pharmacological landscape of the autistic brain

Functionally inter-connected large-scale brain networks regulated by multiple neurotransmitter systems underpin complex human behaviour. A wide range of alterations in this neurofunctional landscape have been associated with autism. However, this evidence is mostly derived from c...