Mount Sinai Hospital

Marginal excision of dedifferentiated liposarcoma of the limbs without radiation may be safe in select patients

Aims Dedifferentiated liposarcoma (DDLPS) is a heterogeneous tumour consisting of low-grade atypical lipomatous tumour (ALT) and high-grade sarcomatous components. This study evaluates local recurrence and metastasis rates after resection of a limb DDLPS, focusing on the impact o...

Brain injury after single fetal demise in monochorionic twin pregnancies: an international multicentre retrospective cohort study

Background Single fetal demise (sFD) in monochorionic (MC) twins may lead to acute exsanguination through placental anastomoses and result in brain injury in initially surviving cotwins. We aimed to evaluate the prevalence, type, severity, and factors associated with brain injury...

Prediction of Vaginal Delivery in Pregnant Individuals with Class III Obesity Undergoing Induction of Labor: Development and Internal Validation of a Prediction Model

Objective: The objective of this study was to develop and internally validate a model predicting vaginal delivery after labor induction in individuals with class III obesity, and to describe maternal and neonatal outcomes by delivery mode. Methods: This was a retrospective cohort...

Identification and characterization of neoplastic cells in keratin-positive giant cell–rich tumors

Keratin-positive giant cell–rich tumor (KPGCT) is a newly described bone and soft tissue tumor. The tumor is characterized by scattered keratin-positive cells and the presence of HMGA2::NCOR2 fusions. It is not known if the HMGA2::NCOR2 fusion is located in the keratin-positive c...

Canadian evidence‐based guidelines on spinal procedures for chronic pain

Summary Introduction Interventional procedures are commonly used to diagnose and treat chronic pain of spinal origin but guidance on: their indications; frequency; technical conduct; requirements for image guidance; outcome measurement; and management of complications is lacking....

A Remotely Delivered Exercise-Based Rehabilitation Program for Patients with Persistent Chemotherapy-Induced Peripheral Neuropathy (EX-CIPN): A Phase I Feasibility Trial

Background: Chemotherapy-induced peripheral neuropathy (CIPN) affects two-thirds of patients who receive neurotoxic chemotherapy. In almost half of these patients, CIPN is persistent, with limited treatment options. Exercise-based rehabilitation shows promising results in improvi...

Exploration of the genetic architecture of ANCA-associated vasculitis

Background Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a complex autoimmune disease with distinct clinical and serological subtypes. Previous genome-wide association studies (GWAS) have identified several susceptibility loci, particularly within the major h...

Vascular device practices in extremely preterm infants: an international cross-sectional survey

Abstract Objective To explore global practices in vascular device selection, securement, and monitoring for extremely preterm infants, and to assess regional variation. Study design A web-based cross-sectional survey was completed by one respondent per neonatal unit. Result We re...

No difference in alloimmunization of pregnant adults with sickle cell disease exposed to chronic versus on‐demand transfusions: A two‐center retrospective cohort study

Abstract Background Pregnant people with sickle cell disease (SCD) experience high morbidity and mortality, even when RBC transfusion is safe and available. There is a lack of consensus on transfusion use partly due to concern for alloimmunization. This study examined alloimmuniz...

Cost-Effectiveness Analysis of Ribociclib plus an Aromatase Inhibitor (AI) Versus AI Alone in the Adjuvant Treatment of Stage II and III Pre- and Postmenopausal Women with HR+/HER2− Early Breast Cancer (EBC): A Canadian Payer Perspective

Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors have transformed the treatment of hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2−) breast cancer. Ribociclib plus an aromatase inhibitor (AI) was approved in Canada as adjuvant treatment...

Spatial transcriptomic analysis of progressing oral epithelial dysplasia reveals unique differentially expressed genes and microenvironmental changes.

Oral squamous cell carcinoma (OSCC) often arises from oral epithelial dysplasia (OED); however, the gene expression changes during OED progression and its microenvironment are not fully understood. This study used spatial transcriptomics to identify differentially expressed genes...

Pregnancy after haematopoietic stem cell transplantation: likelihood, risks, and management

PURPOSE OF REVIEW: Advances in haematopoietic stem cell transplantation (HSCT) have improved long-term survival, making fertility and reproductive health increasingly important aspects of survivorship. This review summarizes current evidence regarding fertility after HSCT, fertil...

Management of Soft Tissue and Visceral Leiomyosarcomas

Importance Leiomyosarcoma is a rare and heterogeneous malignant mesenchymal neoplasm associated with substantial morbidity and mortality. Given recent advances in biologic understanding and the complexity of leiomyosarcoma, a consensus-driven approach is needed to harmonize manag...