Mount Sinai Hospital

New horizons in cooking and mealtime interventions for mild cognitive impairment and early dementia: a scoping review

Background Alzheimer’s disease and related dementias (ADRDs) are increasingly common conditions that are highly disruptive to individuals and families. ADRDs impact cognition and can undermine a person’s ability to participate in cooking, preparing meals, and engaging in conversa...

Identification and characterization of neoplastic cells in keratin-positive giant cell–rich tumors

Keratin-positive giant cell–rich tumor (KPGCT) is a newly described bone and soft tissue tumor. The tumor is characterized by scattered keratin-positive cells and the presence of HMGA2::NCOR2 fusions. It is not known if the HMGA2::NCOR2 fusion is located in the keratin-positive c...

Exercise and Thoracic Aortic Aneurysms: A Paradigm Shift Toward Informed, Personalized Activity Guidelines

Exercise is widely recognized for its cardiovascular benefits; however, its safety and role in patients with thoracic aortic aneurysms (TAAs) remains complex due to its distinctive biomechanical vulnerabilities. Fundamentally different from abdominal aortic aneurysms, TAAs develo...

Artificial Intelligence for Cardiac Ischemia Detection: A Review of Biosensor, Biomarker, and Imaging Applications

Ischemic heart disease is the leading cause of global mortality, yet accurate and timely detection remains constrained by incomplete signal capture, noise, operator dependence, and imperfect reference standards. Artificial intelligence (AI) may enhance cardiovascular sensing by e...

Promotion of long-term health in early life

Noncommunicable chronic diseases (NCDs) are on the rise in high-income countries, leading to substantial morbidity and mortality and contributing to increased resource demands and healthcare costs. Early-life exposures can initiate trajectories that culminate in NCDs later in lif...

Antithrombotic therapy after percutaneous coronary intervention in patients with atrial fibrillation: an individual patient data network meta-analysis

BACKGROUND AND AIMS: Randomized trials demonstrated that in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) direct oral anticoagulants (DOAC) and a P2Y12 inhibitor reduce bleeding compared with vitamin K antagonist (VKA) plus dual antipl...