Morehouse School of Medicine

CfDNA methylation profiling in blood following moderate-to-severe traumatic brain injury using brain cell type–enriched signatures: A pilot study

The human brain consists of diverse cell types that collaboratively perform complex functions and form intricate neuronal networks. When traumatic brain injury (TBI) occurs, multiple molecular pathways involving diverse cell types are activated in response to injury. Understandin...

Acidic cannabinoids in brain disorders: Neurobiological mechanisms, preclinical evidence, and translational challenges

Acidic cannabinoids, including tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabigerolic acid (CBGA), and related biosynthetic precursors, represent the predominant phytocannabinoid forms naturally produced by Cannabis sativa . Long considered pharmacologicall...

Performance and safety of a multi-cancer early detection test: the PATHFINDER 2 study

Abstract Early cancer detection improves survival; however, most cancer types do not have guideline-recommended screening. We previously reported the first PATHFINDER study that established feasibility of cancer screening with a blood-based multi-cancer early detection (MCED) tes...

The Privacy–Support Paradox of AI-Based Employee Stress Management: The Role of Perceived Surveillance, Explainability, Trust, and Employee

Abstract New organizational ATPs are adopting artificial intelligence (AI) across various tools to detect and mitigate employee stress – sentiment analysis, facial-emotion analytics, wearable biosensors, and AI-powered counselling via chatbots. While the technology behind these s...

Caspase-3 dependent, induction of barrier dysfunction and hyperpermeability in blood-brain barrier endothelial cells

BACKGROUND: Blood-brain barrier (BBB) dysfunction and associated microvascular hyperpermeability lead to brain edema and elevation of intracranial pressure in traumatic and ischemic brain injuries. Pro-inflammatory cytokines, interleukin (IL-1β) and tumor necrosis factor (TNF-α),...

Millimeter-wave directed energy-mediated neural cell injury: insights into protein degradation and cell injury mechanisms

Background: Millimeter-wave directed energy (mmWave DE) is increasingly used in telecommunications and military applications, yet its biological effects on neuronal systems remain unclear. To characterize the spatially dependent cellular and molecular impacts of 34.14 GHz mmWave...

Unintentional Intra-Implant Fat Injection During Breast Fat Grafting

Background: Fat grafting is commonly used in implant-based breast reconstruction to improve contour and soft-tissue quality. Cannula-related implant injury during fat grafting is considered rare and is infrequently discussed in the literature. Methods: A focused review of PubMed...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...