Morehead State University

Rates of Evolution Differ Between Cell Types Identified by Single‐Cell RNAseq in Threespine Stickleback

ABSTRACT Rates of evolutionary change vary by gene. While some broad gene categories are highly conserved with little divergence over time, others undergo continuous selection pressure and are highly divergent among populations or species. But such comparative evolutionary studie...

Acoustic shadows and array performance at offshore wind monopile foundations: quantifying trade-offs for telemetry array design

Abstract Background Offshore wind energy development introduces large-scale structures into marine environments. Acoustic telemetry is increasingly employed to monitor fish responses to offshore wind infrastructure, including via regulatory monitoring programs, yet practical guid...

DdrR acts as a DNA damage-induced cell division inhibitor in Acinetobacter baumannii

ABSTRACT The genus Acinetobacter possesses non-canonical genes and responses to DNA damage. It encodes no LexA homolog to repress the ~150 SOS genes induced after exposure to various DNA-damaging agents, but two SOS regulators, UmuDAb and DdrR, repress both themselves and error-p...

Suzetrigine as Part of Multimodal Therapy Enables Opioid-Free Recovery after Laparoscopic or Arthroscopic Procedures

Suzetrigine, a non-opioid voltage-gated sodium channel 1.8 (Na V 1.8) pain signal inhibitor with no addiction potential, is approved in the USA for moderate-to-severe acute pain. In this phase 4, single-arm study, suzetrigine (100 mg preoperatively, then 50 mg every 12 h) was adm...