Moorfields Eye Hospital NHS Foundation Trust

Autosomal Recessive RDH12-Leber Congenital Amaurosis Retinal Organoids Suggest Phospholipid Pathway Dysregulation

NADPH-dependent retinol dehydrogenase 12 (RDH12) reduces all-trans-retinal in photoreceptor inner segments to regulate the phototransduction cascade and control the concentration of retinoids in the retina. Variants in RDH12 have been reported to cause an array of retinal disease...

Three-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis and goniotomy for advanced primary angle-closure glaucoma: a multicentre study

Aims To assess the 3-year efficacy and safety of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL) and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract. Methods This was a multicentre prospective observational study with ext...

Visual crowding in infantile idiopathic nystagmus is not reduced by differences in target-flanker elements

Foveal vision in individuals with infantile idiopathic nystagmus syndrome (IINS) is impaired by reduced acuity and elevated crowding (the disruption in object recognition from clutter). In typical peripheral vision, acuity can be improved by temporal variations (flicker), while c...

Customized chatbot for patient education in vitreoretinal diseases

Abstract Purpose To develop and evaluate the accuracy and safety of a customized, domain-restricted chatbot providing postoperative patient education after vitreoretinal surgery. Methods We evaluated a domain-restricted GPT-4 chatbot accessed through the OpenAI API and implemente...

Microbial keratitis management through the lens of pharmacy attendants in Siraha district of Nepal: A study of knowledge, attitudes, and practices

Background Microbial keratitis (MK) is endemic in many developing countries including Nepal and is a preventable cause of blindness. Many Nepalese rely on community pharmacies or medical shops as their primary source of healthcare. This study explored the knowledge and experience...

Patient-Reported Exposure to Potentially Bogus Ophthalmic Treatments

This survey study examines how ophthalmic patients encounter treatments they perceive as bogus and whether the source of exposure is associated with subsequent treatment uptake.

Clinical Features of Acquired Esotropia and Surgical Management in a Real-World Cohort of Myopic Patients

BACKGROUND: The global increase in myopia prevalence has led to greater interest in associated esotropias. While myopic patients can present with common or special forms of strabismus (e.g., "heavy eye syndrome"), the relative incidence of associated strabismus and best surgical...

Macular neovascularisation subtype determines visual consequences of early fibro-atrophic remodelling in neovascular AMD: PRECISE study report 11

Abstract Purpose To evaluate whether baseline well-delineated hyperreflective material (wdHRM) is associated with short-term visual outcome in treatment-naïve neovascular age-related macular degeneration (nAMD), whether this association differs by macular neovascularisation (MNV)...

Developing a scalable pipeline for data extraction from clinical letters through resource-efficient prompt engineering

<title>Abstract</title> Free-text clinical records represent an untapped wealth of data for secondary use. Their potential is limited by resource demands necessary for accurate information extraction at scale. We introduce a scalable, resource-efficient, and high-performance pipe...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...