Moorfields Eye Hospital

Choroidal Tuberculosis in Miliary Disease: A Multimodal Imaging Spectrum Across Iatrogenic and Disease-Mediated Immunosuppression

Purpose To describe the multimodal imaging findings of choroidal tuberculosis in two cases of miliary tuberculosis occurring in the setting of distinct forms of immunosuppression.Method Retrospective analysis of four eyes with miliary choroidal tuberculosis.Results Case 1 was a y...

Autosomal Recessive RDH12-Leber Congenital Amaurosis Retinal Organoids Suggest Phospholipid Pathway Dysregulation

NADPH-dependent retinol dehydrogenase 12 (RDH12) reduces all-trans-retinal in photoreceptor inner segments to regulate the phototransduction cascade and control the concentration of retinoids in the retina. Variants in RDH12 have been reported to cause an array of retinal disease...

Visual crowding in infantile idiopathic nystagmus is not reduced by differences in target-flanker elements

Foveal vision in individuals with infantile idiopathic nystagmus syndrome (IINS) is impaired by reduced acuity and elevated crowding (the disruption in object recognition from clutter). In typical peripheral vision, acuity can be improved by temporal variations (flicker), while c...

OphthoEvidence Report: Comparative effects of treatments for geographic atrophy secondary to age-related macular degeneration: A protocol for a living systematic review and network meta-analysis

Background Geographic atrophy (GA), an advanced form of age-related macular degeneration (AMD), leads to legal blindness in approximately 16% of affected individuals within 6 years. Numerous trials have evaluated interventions to slow GA progression, and many studies are ongoing....

Patient-Reported Exposure to Potentially Bogus Ophthalmic Treatments

This survey study examines how ophthalmic patients encounter treatments they perceive as bogus and whether the source of exposure is associated with subsequent treatment uptake.

Real-World Clinical Management of Keratoconus in Europe and the Middle East: A Multicountry Survey on Diagnostic and Surgical Practices (Keratoconus in Mind - KIM Project)

Purpose: This study aimed to describe the current management of patients with keratoconus in European and Middle Eastern countries through the collection of real-world data from clinicians actively managing keratoconus. Methods: Computer-assisted web interviewing survey targeting...

Visual impairment certifications in England over 16 years: annual numbers attributable to age-related macular degeneration, glaucoma, diabetes and hereditary eye disease

Individuals meeting certain criteria of sight impairment or severe sight impairment are eligible for a Certificate of Vision Impairment (CVI), which can facilitate access to support [ 1 , 2 ]. When the certificate is issued, the main cause of vision impairment is recorded. Here,...

Developing a scalable pipeline for data extraction from clinical letters through resource-efficient prompt engineering

<title>Abstract</title> Free-text clinical records represent an untapped wealth of data for secondary use. Their potential is limited by resource demands necessary for accurate information extraction at scale. We introduce a scalable, resource-efficient, and high-performance pipe...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...