Monash Medical Centre

Early Introduction and Prolonged Full‐Dose Anakinra Reduce Recurrence Risk After Discontinuation in Recurrent Pericarditis: An International Multicenter Cohort

Background Anakinra is effective in recurrent pericarditis, yet optimal treatment duration and strategies for safe drug discontinuation remain uncertain. Identifying predictors of sustained remission after discontinuation is important for clinical management. Methods We retrospec...

Reducing Peripheral Intravenous Catheter Use in Adult Acute Care: A Systematic Review

ABSTRACT Peripheral intravenous catheters (PIVCs) are the most frequently inserted invasive device in acute care, yet up to 52% remain unused, exposing patients to avoidable risks and increasing healthcare costs. Despite growing awareness of inappropriate PIVC use, unnecessary in...

Early life trauma and endometriosis: A case-control study on type and timing of adverse experiences

PURPOSE: Endometriosis is a common chronic inflammatory gynaecological condition characterised by the abnormal presence of endometrial tissue outside the uterus. Different risk factors for endometriosis have been proposed, with some research finding a significant relationship bet...

Efficacy and safety of canagliflozin are consistent across polypharmacy burden in CKD: the CREDENCE trial

Abstract Background Polypharmacy in chronic kidney disease (CKD) is substantial. Clinicians and patients are often reluctant to add medications to already complex regimens, partly due to concerns about diminishing efficacy and increased adverse effects. We assessed whether effica...

The effect of augmented protein intake on nitrogen balance: A nested cohort study of the TARGET protein trial

Purpose The impact of augmenting enteral protein delivery on nitrogen balance, urea generation, and kidney function in critically ill patients remains poorly defined. This study aimed to investigate these effects in a nested cohort within the TARGET Protein trial. Methods We cond...

Scaling up Genomics

Introduction: Genomic testing has substantial diagnostic and clinical value in nephrology, yet integrating testing into routine care requires service-level changes to ensure timely and equitable access. Methods: We conducted an observational cohort study at four tertiary centres,...

‘So many relationships in the room’: Participant perspectives on the affordances and challenges of co‐therapy in psychedelic assisted therapy

OBJECTIVES: Psychedelic-assisted therapy (PAT) frequently utilises a "cotherapy" model, in which two therapists jointly support participants throughout dosing and psychotherapy sessions. While common in clinical trials, participant experiences of cotherapy remain underexplored. T...

The Effect of Using Write‐Zoom for Volume Flow Measurements in Haemodialysis Fistulas

ABSTRACT Introduction Arteriovenous fistulas (AVFs) are crucial for patients undergoing haemodialysis, yet about 25% fail to mature or experience early failure. Ultrasound is key in managing AVFs, with volume flow (Qa) serving as a predictor of maturation. Accurate Qa measurement...