Moffitt Cancer Center

Systemic Therapies in Advanced Adrenocortical Carcinoma: Current Standards, Emerging Strategies, and Practical Considerations

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy characterized by marked biological heterogeneity and a high risk of recurrence and progression. While complete surgical resection remains the foundation of treatment for those with localized disease, systemic therapy i...

Treatment-Requiring Postoperative Nausea and Vomiting in Ambulatory Oncology Surgery: Four-Year Trends in Antiemetic Utilization

Background/Objectives: Postoperative nausea and vomiting (PONV) remains an important complication after ambulatory cancer surgery. This study evaluated four-year trends in treatment-requiring post-anesthesia care unit (PACU) PONV, prophylactic aprepitant utilization, and rescue a...

Validation of the International Working Group 2023 response criteria for higher risk myelodysplastic syndromes/neoplasms using the International Consortium for Myelodysplastic Syndromes VALIDATE database and a randomized phase III trial

Response assessment criteria in patients with higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) have been updated in the 2023 International Working Group (IWG) criteria. However, validation of these criteria has been limited to date. We analyzed overall survival (OS) by be...

Intratumoral Immunotherapy—The Future of Treating Merkel Cell Carcinoma?

Merkel cell carcinoma (MCC) represents a rare but highly aggressive neuroendocrine skin cancer with limited systemic therapy options for patients who fail or are ineligible for immune checkpoint inhibitors (ICIs). Intratumoral (IT) immunotherapy has emerged as a promising strateg...

CAR signaling instructs divergent metabolic reprogramming and functional fates in αβ and γδ T cells

γδ T-cell-based immunotherapies have become relevant as alternatives to conventional αβ T-cell products, with preclinical data demonstrating tumor burden reduction and the mitigation of tumor-induced tissue damage. Given that most CAR constructs have been optimized for αβ T cells...

Real‐world outcomes of nivolumab‐ AVD and brentuximab vedotin‐ AVD in paediatric and adult advanced‐stage Hodgkin lymphoma

Summary Brentuximab vedotin (BV)‐doxorubicin, vinblastine and dacarbazine (AVD) and nivolumab (N)‐AVD have transformed the frontline treatment of advanced‐stage Hodgkin lymphoma (HL), yet real‐world comparative data remain limited. In this multicentre retrospective study across 1...

Development of a Citrate Reaction Grading and Treatment Chart for Patients Undergoing Leukapheresis Procedures

ABSTRACT Calcium supplementation to prevent or treat hypocalcemic symptoms during leukapheresis is not standardized. Institutions vary in practice. Within an institution, there is also nursing variability. Recognizing the need to harmonize our practices, the apheresis nurses at o...

Preoperative Prediction of Ductal Carcinoma In Situ Upstaging Using Machine Learning‐Based Peritumoral Breast MRI Radiomics

BACKGROUND: A subset of biopsy-confirmed ductal carcinoma in situ (DCIS) cases can be upstaged to invasive breast cancer at surgery. Preoperative identification of upstaging risk is essential for treatment planning. PURPOSE: To develop clinical and breast MRI radiomics models to...

Safety and financial analysis of outpatient HyperCVAD arm A administration for acute lymphoblastic leukemia

IntroductionOur institution transitioned the administration of hyperCVAD arm A to the outpatient setting via an Inpatient/Outpatient (IPOP) program. This study aims to evaluate the safety and financial impact of administering hyperCVAD arm A in the outpatient setting.DesignRetros...

A rare right perirenal hemangioma mimicking a retroperitoneal “malignant lesion”: Diagnostic and procedural challenges of an extra-renal vascular mass

Perirenal hemangiomas are rare benign vascular tumors that can present as indeterminate retroperitoneal masses and mimic renal, adrenal, or soft-tissue malignancy. We report the case of a 60-year-old woman who was incidentally found to have a right perirenal mass adjacent to the...

In vivo Tracking of Clonal Dynamics in UV-Induced Skin Carcinogenesis Reveals Tumor Development from Goliath Clades

Abstract While the genetic paradigm of cancer is powerful, it remains incomplete. For example, high mutational burdens are commonplace in homeostatically-stable epithelia, but the presence of driver mutations alone does not result in cancer. Here, we revealed additional factors c...

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

Targeting TGFBR1 with the Investigational Inhibitor TP-6379 Improves Hematopoiesis in Low-Risk MDS Ex Vivo

Myelodysplastic syndrome (MDS) is characterized by S100A9-mediated constitutive innate immune activation that leads to the inflammatory death of hematopoietic stem/progenitor cells (HSPCs). This suppressive microenvironment includes the secretion of TGFβ and is phenocopied by the...

What are the Unmet Needs in Managing Digestive Neuroendocrine Carcinomas?

This review highlights the major unmet needs in diagnosis and treatment of digestive neuroendocrine carcinomas (NEC) and describes the current and evolving evidence on these aspects. Improved pathological criteria are needed to accurately diagnose NEC and distinguish this entity...

Outcomes of CHOP versus CHOEP/EPOCH in aggressive adult T-cell leukemia/lymphoma: an international cohort analysis

Aggressive adult T-cell leukemia/lymphoma (ATL) subtypes (i.e., acute and lymphomatous) are rare diseases, and the conventional management with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) has historically yielded poor outcomes. The benefit of etoposide-conta...

Large Calyceal Diverticulum Mimicking a Solid Renal Mass in a Patient Undergoing 68Ga-DOTATATE PET/CT

A 41-year-old man with grade 1, well-differentiated neuroendocrine tumor (NET) of the terminal ileum underwent initial staging with 68Ga-DOTATATE PET/CT. PET/CT images demonstrated focal uptake at the terminal ileum corresponding to the patient's known NET. In addition, a large,...

Extracellular Matrix Remodeling in Tumors: Forces Beyond Fibroblasts

Aberrant extracellular matrix (ECM) remodeling in tumors is characterized by altered deposition, enzymatic cross-linking, degradation, and organization of matrix molecules that in turn can contribute directly to tumor invasiveness, immune evasion, and resistance to therapy. Tradi...

Epidemiology and Species Distribution of Candida Bloodstream Infections in a Comprehensive Cancer Center, 2008–2023

Abstract Introduction Candida bloodstream infections remain a significant complication of malignancies and their therapies. Aim To investigate the epidemiology of Candida species causing bloodstream infections in patients with malignancies. Methods We retrospectively reviewed blo...

Trends in Treatment and Survival Among Patients with Glioblastoma in the United States from 2000 to 2020

Background: Population-level patterns in the real-world use of initial treatment combinations for glioblastoma (GBM) remain poorly characterized. Materials and Methods: We assessed temporal trends in treatment and survival among patients with GBM in the SEER registry. Guideline-c...

A Multilevel Intervention to Identify Individuals for Genetic Testing and Treatment

Importance Cascade genetic testing (CGT) is a key strategy for cancer prevention in families with hereditary breast and ovarian cancer syndrome (HBOC) and Lynch syndrome (LS), yet uptake among at-risk relatives remains persistently low, particularly in medically underserved popul...