Moffitt Cancer Center

DNA methylation modulation by 5-Azacytidine regulates EMT markers and reduces invasiveness in docetaxel-resistant prostate cancer cells

<title>Abstract</title> <bold>Background:</bold> Metastatic castration-resistant prostate cancer (mCRPC) is associated with poor prognosis and high mortality, largely due to the emergence of androgen and chemotherapy resistance. Resistance to docetaxel occurs in nearly 50% of pat...

Synthesis of the A/B ring system of withaferin A-type withanolides

Withanolides are C28 steroidal lactone plant-based natural products with diverse pharmacological activities, yet their synthesis remains challenging owing to the highly oxidized A/B ring system. Herein, we report a concise, protecting group-free route to the 1‑oxo‑2‑ene‑4β‑hydrox...

Multidimensional LDCT Imaging Endpoints for a Randomized Pilot Phase II Trial of Curcumin and Omega-3 Fatty Acids for Lung Cancer Chemoprevention: Results of a Randomized Pilot Trial

Background: Former and current smokers in lung cancer screening remain at elevated risk for lung cancer despite smoking cessation. We and others have shown that curcumin (CUR) exhibits anti-inflammatory and antiproliferative effects but is limited by poor bioavailability. However...

Fisher Information Limits on Genetic Stability, Diversity, and Regulation

Abstract Life and evolution require precise yet imperfect transmission of genetic information across generations. Accurate transmission maintains the genetic blueprint for phenotypes that succeed in current conditions, while some transmission error is necessary to generate herita...

Density dependence and evolvability limit adaptive therapy in non-small cell lung cancer mouse model

Abstract Using NSG mice grafted with H3122 non-small cell lung cancer cells, we compared outcomes from (1) continuous therapy with alectinib, (2) adaptive therapy where alectinib was cycled on and off based on a mouse’s tumor burden, and (3) no treatment. Adaptive therapy has pro...

Surgical Management of Young Women with High-Risk Breast Cancer Receiving Neoadjuvant Systemic Therapy on the I-SPY2 Trial

BACKGROUND: Mastectomy rates in women with breast cancer are higher in younger women than in older women. The impact of this more extensive surgery on overall survival (OS) and locoregional recurrence in younger women is unknown, especially after neoadjuvant systemic therapy (NST...

Blinatumomab versus chemotherapy in pediatric B-ALL: A meta-analysis of randomized trials in relapsed and high-risk frontline disease

BACKGROUND: B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric cancer, comprising almost 25 % of childhood malignancies. Despite advances in chemotherapy, relapse remains a major cause of treatment failure, particularly in high-risk patients. Blinatumomab, a...