Model Animal Research Center

The mechanosensitive channel TMEM63B contributes to noxious heat sensation in the dorsal root ganglia

In mammals, heat sensation is primarily mediated by thermosensitive channels, particularly transient receptor potential (TRP) channels, in dorsal root ganglion (DRG) neurons. However, whether additional channels contribute to noxious heat detection remains unclear. Here, we inves...

Inhibition of neuronal DICER–miR-34a/346 signaling attenuates amyloid pathology in 5×FAD mice

MicroRNAs (miRNAs) are critical regulators of genes underlying Alzheimer’s disease (AD) pathogenesis, yet the role of neuronal DICER, a key ribonuclease essential for miRNA maturation, remains unclear. While biochemical analysis of human postmortem cortical tissues revealed upreg...

Baseline Cortisol and Behavioral Phenotype Are Linked to Context‐Dependent Spatial Cognition and Space Use in Giant Pandas

Animals differ consistently in how they respond to novelty and environmental change, but whether such variation links endocrine state, spatial cognition, and space use remains unresolved. In giant pandas (Ailuropoda melanoleuca), we combined novel object tests, a resource-change...