Mitchell Institute

The Simons Observatory: Development of a Pipeline to Detect Rapid Transients in Time-Ordered Data

We introduce a method for detecting astrophysical transients evolving on timescales of milliseconds to minutes using cosmic microwave background (CMB) survey telescopes. While previous transient searches in CMB data operate in map space, our pipeline directly processes the raw ti...

Platforming the womb: GarbhSanskar Guru, archaic modernity, and the reproductive politics of an Ayurveda app

GarbhSanskar Guru, a contemporary pregnancy and pregnancy-planning app, turns garbh sanskar into a daily interface of maternal instruction. It promises support – diet and lifestyle advice, baby bonding, trackers, live expertise and personalized activities – while organizing pregn...

PSYCHIATRIC GENOMICS CONSORTIA ANXIETY PHASE 2: DISAGGREGATING GENOMIC EFFECTS ON INDIVIDUAL ANXIETY DISORDERS AND DELVING INTO BIOLOGICAL MECHANISMS

Overall Abstract The recent PGC-ANX flagship publications of their case-control and dimensional anxiety genome-wide association studies (GWAS) have established a robust foundation for investigating the genomic and biological underpinnings of anxiety-related distress and impairmen...

Perceptions of CRISPR and the role of risk information seeking and processing: An analysis of North Carolina consumers

Genetic engineering technologies, like CRISPR, have ignited public acceptance issues due to perceived risks and previous rejection of genetically modified organisms. Thus, there is a need for evidence-based strategies to inform effective science communication and outreach. The cu...

Oral Health Indicators as Important Predictors of Frailty in Korean Adults Aged 50 Years and Older: A Sex-Stratified Explainable Machine Learning Approach

Background Frailty is a major public health concern, yet oral health indicators are rarely incorporated into prediction models. Objective To develop sex-stratified explainable machine-learning models for frailty prediction. Methods Cross-sectional data from 12,302 adults aged ≥50...

Wave Energy Contributions from Hurricanes, Front Events, and Vessel Passages near Coastal Wetland Edges in Galveston Bay

Abstract Coastal wetland erosion is a significant environmental concern along the Texas coast with various contributing factors. This paper evaluates wave activity at four coastal field sites near the Gulf Intracoastal Waterway (GIW) in Galveston Bay and quantifies the contributi...

5-Fluorouracil-based chemotherapy disrupts autophagy flux and protein synthesis in cultured myotubes: a role for mTORC1 signaling

5-Fluorouracil-based chemotherapies, such as FOLFOX (5-fluorouracil, leucovorin, oxaliplatin), are used to treat colon cancer but also induce skeletal muscle toxicities. While FOLFOX can disrupt muscle autophagy signaling in vivo, the upstream mechanisms underlying this effect, a...

How Internal Cognitive Style and External Visual Clutter Shape Inattentional Blindness and Safety Risk Perception on Construction Sites

Abstract Construction supervisors’ failure to recognize hazards contributes to accidents, and these failures occur at two distinct stages. A supervisor may not notice a hazard, or may notice it but not judge it a safety risk. This study examines how an internal factor, cognitive...

QuantumCanvas: a multimodal benchmark for learning two-body quantum interactions

Abstract Most molecular and materials machine-learning models fit correlations across whole molecules or crystals rather than learning the quantum interactions between atomic pairs. Yet bonding, charge redistribution, orbital hybridization, and electronic coupling all emerge from...

Phase-Induced Particle Creation in the Kappa-Gamma Vacuum

Abstract The $\kappa$ plane wave construction describes a one-parameter family of vacua as continuous-mode squeezed states of the Minkowski vacuum, with a real, frequency-dependent squeezing magnitude set by a single scale $\kappa$. Here we promote this real squeezing to complex...

Cognitive Workload Assessment in Procedural Tasks

Objective To examine how task anomalies and time pressure influence cognitive workload in procedural tasks and to identify whether workload effects are transient or sustained. Background Procedural tasks often involve sequential actions for which disruptions, such as operational...

Multiparametric optimization based decision making approach in energy systems planning under uncertainty

Energy infrastructure planning confronts a fundamental temporal asymmetry in which capacity decisions must be committed before uncertainty materializes and yet must remain robust across all future operational scenarios. Traditional approaches either adopt worst-case hedging or ig...

Improved specificity of a probe-based real-time PCR for the detection of Dirofilaria immitis in canine blood

Abstract Background Dirofilaria immitis is a vector-borne filarioid nematode distributed worldwide and endemic across most of North America. In dogs, it is considered the most important parasite and a known cause of acquired cardiomyopathy. Clinically, canine heartworm disease ca...

Dissociable Roles of Primary Motor and Supplementary Motor Cortex in Shaping the Neural Drive to Muscle

Abstract The primary motor cortex (M1) and supplementary motor area (SMA) are critical for motor execution and planning, yet their distinct causal contributions to modulating the neural drive to muscles remain incompletely understood. To dissociate their roles, we applied inhibit...

The impact of work from home on urban expansion: a GIS simulation via an intelligent self-adapting multiscale agent-based model

Urban land use is increasingly shaped by evolving work modalities, particularly the rise of Work from Home (WFH) arrangements. This study introduces a hybrid Artificial Neural Network – Agent-Based Modeling (ANN – ABM) framework to simulate urban expansion under differentiated wo...

Examining smartphone-assessed executive function metrics and intrinsic resting-state functional connectivity in depression

<title>Abstract</title> Major Depressive Disorder (MDD) is a common and costly mental health condition that is often associated with deficits in executive function. Smartphone applications (“apps”) have emerged as promising methods for assessing mental health-related outcomes in...

EduCase: A Systematic Framework for Developing Educational Case Studies in Construction and Engineering Education

Abstract Despite the critical role of educational case studies in construction and engineering education (CEE), there is a lack of systematic frameworks for developing effective educational case studies. This study introduces the educational case study development (EduCase) frame...

Constraint-Based DEM Enhancement Using LiDAR Data at Sparse Highway-Bridge Locations

Abstract Digital elevation models (DEMs) are essential for infrastructure design and flood modeling, yet publicly available DEMs typically exhibit vertical accuracies of one to three meters, insufficient for these applications. This study develops and systematically evaluates a c...

Detailed study of non-equilibrium characteristics of quasi-neutral TNSA plasmas

In an experiment performed in November 2022 at the petawatt (PW) laser facility at Vega III located in Salamanca-Spain, we have studied the successful production of several radioisotopes using protons accelerated by the Target Normal Sheath Acceleration (TNSA) mechanism (Rodrigue...