Ministry of Interior

Chemical Profiling and In Vitro Cytotoxicity Assessment of Commercial Red Yeast Rice Ingredients

Red yeast rice (RYR) food supplements are widely used for cholesterol management due to their monacolin content, particularly monacolin K (MK), which shares the same chemical structure as lovastatin, a compound associated with several side effects. The European Food Safety Author...

Efficacy and tolerability of venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukemia – real-world analysis of Polish adult leukemia study group

We collected clinical data on 363 patients with relapsed/refractory chronic lymphocytic leukemia (RR-CLL) treated with venetoclax-rituximab (VR) in a real-world setting. The median age was 69.5 years (range, 32.5–91.6 years), and the median number of prior lines of therapy was 2...

Intra-Articular Monoclonal Antibodies in Temporomandibular Joint Disorders: Current Evidence

Immune-mediated temporomandibular joint disorders involve cytokine-driven inflammation and may represent a target for biologic therapy. This paper summarizes the evidence on intra-articular monoclonal antibody administration in temporomandibular joint disorders. PubMed, Europe PM...

Clinical Meaningfulness and Improvement Thresholds of Myositis Core Set Measures: Association with Patient-Reported Outcomes

Objective The study aimed to evaluate the clinical meaningfulness and improvement thresholds of the myositis core set measures (CSMs) of disease activity in idiopathic inflammatory myopathies (IIM), emphasizing associations with patient-reported outcome measures (PROMs). Methods...