Ministry of Health of the Russian Federation

Panel-Specific Optimization and Benchmarking of Copy-Number Callers for ERBB2 Amplification Detection Using the Nanodigmbio NanOnco Plus Panel v3.0

Background/Objectives: ERBB2 amplification is a clinically relevant breast-cancer biomarker, but CNV detection from targeted sequencing depends on assay design, normalization, tumor fraction, and decision rules. We evaluated panel-specific ERBB2 analysis configurations against a...

Microbiome-Related Amino-Acid Profiles of Liver and Muscle Tissues in Arbor Acres Broiler Chickens

The study, designed as a group-level integrative data analysis, included homogeneous datasets obtained from 24 Arbor Acres chicken groups. Quantitative amino-acid analysis in chicken tissues was carried out using the capillary electrophoresis method. Gut microbial community analy...

Targeting ferroptosis in cancer: molecular mechanisms and emerging therapeutic strategies

Ferroptosis, an iron-dependent form of regulated cell death characterized by the lethal accumulation of lipid peroxides, has emerged as a pivotal pathway in cancer biology and a promising therapeutic target. This review synthesizes the core molecular machinery governing ferroptos...

Bowel preparation for colonoscopy: current strategies. A narrative review

Objective. To summarize current evidence on the principles of bowel preparation for colonoscopy. Key points. The quality of bowel cleansing is an independent quality indicator of colonoscopy and affects mucosal visualization, detection of colorectal neoplasia, and the need for re...

Application of Machine Learning Methods for Processing and Analyzing Data from Probe and Optical Microscopy of Biological Objects

Abstract This review systematizes modern machine learning (ML) methods for solving key image processing tasks in optical microscopy (OM) and atomic force microscopy (AFM). Traditional microscopy data analysis methods face problems of subjectivity, low throughput, and difficulty i...

Analysis of Heterogeneous Biological Preparations in Turbid Media: Limitations of Standard Methods and a Proof-of-Concept Evaluation of Diffuse Reflectance Kinetics

(1) Background: Turbid biological formulations present a challenge for conventional optical protein analysis because scattering and particulate heterogeneity can distort analytical signals. (2) Methods: This study evaluated the limitations of ultraviolet–visible spectroscopy, int...

Comparative analysis of the strength of temporary bridge prostheses with different types of reinforcement framework under immediate load on dental implants

Relevance. Temporary plastic bridge prostheses supported by dental implants, used in immediate loading protocols, often fail due to fracture of the internal reinforcing framework. The optimal configuration of a 1 mm diameter titanium wire framework remains unclear. Objective — to...

The use of methylprednisolone in the comprehensive treatment of the erosive-ulcerative form of the oral lichen planus

Introduction. Oral lichen planus is a chronic multifactorial disease characterized by polymorphic clinical manifestations. Its pathogenesis involves an autoimmune mechanism of inflammation mediated by a T-cell immune response to an unknown antigen (or antigens) in genetically pre...

Assessment of the functional state of the masticatory muscles in patients with a skeletal form of distal occlusion

Objective — to conduct a comprehensive assessment of the functional state of the masseter and temporal muscles in patients with the skeletal form of Class II malocclusion, based on the use of modern diagnostic methods. Material and methods. The study included 20 subjects with nor...

Investigation of the microrelief of the surfaces of dental instruments for finishing restorations made of composite materials with a low-coherence interference installation

A study of the microrelief of the surfaces of dental polishes for finishing composite and compomeric restorations with a low-coherence interference installation has been carried out. The study of the surface of instruments by optical methods and means is an objective, new and eco...

The depth of wound channels of stab wounds of the chest and abdomen as an indicator of the force of a knife strike

The length of the wound channel of a stab wound is a morphological feature that can serve as a criterion for assessing the degree of force of a knife strike. A study of 412 stab wounds to the chest and abdomen in 252 homicide cases showed that clothing, bone-cartilaginous structu...