Ministry of Education

Considerable Anisotropy Magnetoresistance by Oxygen-Mediated Spin State Manipulation in a Highly Textured Multilayer for Ultrasensitive Sensor Application

Spin state manipulation in anisotropy magnetoresistance (AMR) materials is key to improving their transport property for constructing highly sensitive and direction-resolvable magnetic sensors. Currently, the mainstream strategy of tuning the transport property focuses on the mod...

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

ABSTRACT Ethanol‐induced acute gastric mucosal injury (AGMI) remains a prevalent clinical problem, while current therapies are constrained by adverse effects and the immunogenicity of animal‐derived collagens. Here, we evaluate orally administered recombinant human type III colla...

Neural–tumor interactions: bidirectional regulatory mechanisms and nervous system-targeted tumor therapeutic strategies

Neural-tumor crosstalk has emerged as a critical frontier in tumor microenvironment research. Central to this field is the dynamic, bidirectional regulatory network between the nervous system and tumor cells that orchestrates malignant progression. This review focuses on tumors a...

Lewis Acidic Zn/S-1 Zeolite Enables Direct Dehydrogenative Aromatization of Long-Chain Olefins

Abstract Aromatics, as essential chemical feedstocks, are predominantly derived from nonrenewable petroleum resources. With the rapid advancement of syngas–to–olefins (STO) technology, Fischer–Tropsch (F–T) olefin aromatization has emerged as a promising alternative route for aro...

Unraveling umami and kokumi: taste characteristics and molecular mechanisms of milk-derived peptides

Although taste-active peptides have been isolated from enzymatic hydrolysates of defatted high-protein milk powder, their sensory properties, processing stability, and receptor-binding mechanisms remain largely unexplored. In this study, we synthesized milk-derived taste- active...

Cerebellar cortical amyloid deposition biases 18F-Florbetapir PET quantification with whole cerebellum as reference region

To investigate whether cerebellar cortical amyloid-beta (Aβ) deposition biases 18F-Florbetapir Aβ PET quantification when the whole cerebellum (WC) is used as the reference region, and to identify a stable reference region for quantification. Additionally, to establish an optimal...

Application of anisotropic frequency-dependent inversion to shale reservoirs in the Zhaotong Demonstration Area, Sichuan Basin

Abstract The accurate characterization of fracture density and gas saturation is crucial for successful shale gas reservoirs developments. We present an integrated approach that combines rock physics modeling with anisotropic frequency-dependent inversion to characterize shale re...

Whey Protein Peptides Self-Assembled Nanoparticles with Intrinsic Cholesterol Esterase Inhibition Enhance Stigmasterol Bioaccessibility and Hypocholesterolemic Effects

Background: Stigmasterol (St) holds promise as a natural cholesterol-lowering agent, yet its poor aqueous solubility and low bioaccessibility severely constrain its application in functional foods. Methods: In this study, we exploited whey protein peptides (WPP) with intrinsic ch...

Flavor quality evaluation and discrimination of regional tea (Camellia sinensis L.) based on metabolomics, volatileomics, and machine learning

This study aimed to elucidate the differences in the composition of the flavor molecular basis of fresh tea leaves ( Camellia sinensis L.) from different regions and their potential for geographical discrimination. The samples from eight representative producing areas across Chin...

A dimeric mRNA vaccine based on key-mutant and KP.3 RBDs induces broad-spectrum immunity and protects mice against JN.1 and XDV challenges

The continued antigenic evolution of SARS-CoV-2 Omicron subvariants has progressively eroded vaccine-elicited protective immunity, driving demand for next-generation candidates that confer broad-spectrum protection against phylogenetically divergent strains. Here we report the de...

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

ABSTRACT Metabolic remodeling is one of the hallmarks of malignant tumors, and post‐translational modifications of proteins, such as succinylation, play an important role in the process of metabolic remodeling by regulating the function of metabolic enzymes. However, the role of...

Deep Network Reparameterized Full‐Waveform Inversion From Sequential to Simultaneous Sources With Adjoint‐State Method

Abstract Full‐waveform inversion (FWI) relies on sequential‐source (SQ) workflows for high imaging precision, while simultaneous‐source (SML) encoding drastically accelerates computation but introduces irreversible wavenumber discontinuity artifacts in hybrid‐domain implementatio...

Integrated multiomics reveals a clinically relevant CXCL8-centric protein network in pediatric postinfectious bronchiolitis obliterans

Pediatric postinfectious bronchiolitis obliterans (PIBO) is a long-term sequela of severe lower respiratory tract infection. However, the underlying pathogenic mechanisms within the airways remain poorly understood. Bronchoalveolar lavage fluid (BALF) from six children with PIBO...

Spatial Modeling of the Impact of Climate Change on Thermal Comfort Using Geospatial Techniques and Artificial Neural Networks: A Case Study of Northwest Jordan

The extensive use of high-resolution digital elevation data, along with continuous improvements in computing power and geographic information system (GIS) tools. Has driven the development of spatial data processing, management, and spatial interpolation methods. This study aims...

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

ABSTRACT Epstein‐Barr virus (EBV) is a key oncogenic driver of nasopharyngeal carcinoma (NPC) and is closely associated with cisplatin resistance, but its roles in metabolic reprogramming and chemoresistance remain unclear. This study aimed to investigate the role of EBV in polya...

TNF-α-responsive YAP1 promotes CCL20 expression in colorectal inflammation and cancer

Colitis-associated colorectal cancer (CAC) exemplifies how chronic intestinal inflammation can be converted into sustained epithelial programs and a permissive tumor microenvironment, yet the molecular linkage between inflammatory cytokine cues and chemokine outputs remains incom...

The Mediating Role of Strategic Physiognomy in the Relationship Between Strategic Human Resource Development and Organizational Reputation

Abstract : Strategic Human Resource Development (SHRD) has become a fundamental organizational capability for enhancing competitiveness and achieving sustainable organizational success. However, limited empirical attention has been devoted to explaining the mechanism through whic...

Synergistic promotion of white-to-beige adipocyte transition by manganese-nucleic acid framework and allicin for alleviating obesity

Long-term obesity treatment remains challenging due to high costs, adverse drug effects, and invasive surgical procedures. Here, we develop an adipocyte-targeted manganese-nucleic acid framework (MNF) with superoxide dismutase (SOD)-like activity. The MNF and allicin are co-encap...