Ministry of Education

Methyl-donor inhibitors relax 3D genome structures to promote totipotent reprogramming

The 3D genome safeguards cell identity while shaping developmental plasticity, yet its coordination with metabolism during cell fate transitions remains unclear. Here, we use a mouse totipotent stem cell induction system to dissect the role of methyl-donor metabolism in 3D genome...

Multiomics profiling identifies molecular and cellular signatures of regular exercise in human peripheral blood

Regular exercise is well established to protect against metabolic disorders and bolster immunity, but the underlying molecular and cellular mechanisms remain incompletely understood. We integrated plasma metabolomics and lipidomics with single-cell transcriptomic and chromatin ac...

Additive Burden of Low Peak Expiratory Flow and Sleep Disturbance on Incident Depressive Symptoms in Later Life: A Four-Cohort Longitudinal Study of 49,201 Participants

Background: Lung function and sleep are each prospectively associated with late-life depressive symptoms, but whether their co-occurrence carries risk beyond the sum of the two components has not been tested across national populations. Methods: We quantified the joint associatio...

Pretreatment prediction of the response to chemotherapy for spine metastases of breast cancer using histogram signatures from diffusion weighted imaging with multiple b-values: a retrospective study

Pretreatment diffusion weighted imaging (DWI) is effective to predict the response to chemotherapy for spine metastases of breast cancer, but current methods of analyzing DWI data with multiple b-values require a predefined mathematical model for curve fitting. This study propose...

Etching behavior of Y2O3 coatings in a capacitively coupled NF3/Ar/O2 plasma: Effects of bias power and pressure

Yttrium oxide (Y2O3) has been widely used as a protective coating for the inner surfaces of semiconductor process chambers. In NF3-containing plasmas, corrosion may cause coating thinning and surface morphology reconstruction, thereby affecting in-service reliability. To elucidat...

Termination-DependentSynchronous Tuning of Bright-and Dark-Exciton Radiative Lifetimes in Fullerene-Based C36-2D Heterostructures

Abstract Excitons play a central role in optoelectronic, quantum-information, and energy conversion processes, and understanding their radiative recombination behavior is essential for exciton regulation in low-dimensional materials. Here, we employed density functional theory an...

CAFs shape the immunosuppressive microenvironment of pancreatic cancer through the Lin28b-STING Axis

Cancer-associated fibroblasts comprise diverse functionally distinct cellular subsets, with certain subpopulations exerting pivotal influence in shaping the pancreatic cancer immune microenvironment. Here we show that Lin28b+ cancer-associated fibroblasts contribute to establishi...

Development and validation of a nomogram incorporating vascular morphological parameters for prediction of peripherally inserted central catheter-related thromboembolism in cancer patients

Peripherally inserted central catheter (PICC)-related thrombosis (CRT) is a critical complication in cancer patients. However, the impact of vascular morphological parameters on the risk of this complication remains poorly understood. This study aimed to identify independent risk...