Ministry of Education

Receptor-binding geometry constrains viral antigenic evolution through fitness-evasion coupling

Although viral antigenic evolution is shaped by the competing demands of immune evasion and receptor-binding fitness, the physical principles underlying divergent viral evolutionary dynamics remain poorly understood. Here, by integrating structural biology, deep mutational scanni...

Bacterial outer membrane vesicles encapsulating oncolytic virus for targeted nose-to-brain delivery

Oncolytic virus therapy, as an emerging anti-tumor biological therapy, has demonstrated significant therapeutic potential for brain tumors in clinical studies. However, due to the special anatomical barrier of the brain tissue, the application of oncolytic viruses is currently li...

AI‐Enabled Organoid Chips for Modeling and Decoding Nerve‐Tumor Interactions

ABSTRACT The nervous system is emerging as a central regulator of tumor initiation, progression, and therapeutic response. However, the dynamic mechanisms linking neural activity to malignant, immune, and barrier states remain difficult to dissect in vivo. Animal models capture k...

Exposure to Size-Fractioned Ambient Particles Associated with Alterations in Gut Microbiome and Pro-Atherosclerotic Biomarkers in Young Adults

Abstract Background: Ambient fine and ultrafine particles are linked to the progression of atherosclerotic cardiovascular diseases, wherein gut microbiome may play a critical role. However, the underlying mechanisms and relevant metabolic pathways are not yet fully understood. Ob...

Human umbilical cord mesenchymal stem cell-derived exosomes alleviate neurocognitive disorders in chronic obstructive pulmonary disease by suppressing neuroinflammation

Abstract Background Patients with chronic obstructive pulmonary disease (COPD) frequently suffer from COPD-related neurocognitive disorders (COPD-NCDs), which severely impair their quality of life. Neuroinflammation is a key pathological mechanism, but effective therapies are sti...

Tailored Covalent Organic Frameworks Enable the Encapsulation of Living Cells to Produce Rare Ginsenoside

ABSTRACT Whole‐cell catalysis holds great potential in the production of rare ginsenoside compound K (CK), but it is limited by poor mass transfer and inadequate stability in practice. Herein, we report a scalable whole‐cell immobilization platform through in situ assembly of rec...