Ministry of Education

Hydrogen-Associated CXCL2 Drives Adaptive Inflammatory-to-Proliferative State Transition during Skin Wound Healing

Abstract Background Wound healing is an environmentally adaptive process. It requires a tightly coordinated transition from an inflammatory to a proliferative state, which occurs in response to oxidative and inflammatory stress. Molecular hydrogen (H2) is a widely recognized medi...

Enteric-gated nano–probiotic living nanozyme for gut-directed redox–mitochondrial protection in cisplatin-induced acute kidney injury

Oral nano-biohybrid therapeutics provide opportunities for gut–organ axis intervention, but gastrointestinal transit often compromises both probiotic viability and nanozyme activity. Here, we developed CeO 2 @LP@EL, an enteric-gated nano–probiotic living nanozyme constructed by d...

Inflammation-associated hsa_circ_0054391 regulates epithelial-mesenchymal transition and vasculogenic mimicry in colorectal cancer via the miR-1252-3p/VEGFA/ZEB1 axis

Abstract To define the functional role of hsa_circ_0054391 (circ54391) in CRC progression and to evaluate its potential as a serum biomarker. Circ54391 was identified from databases and its expression was validated in CRC tissues, cell lines, and serum from healthy controls ( n =...

Health-convergence-based muscle synergy variability for quantifying neuromuscular control responses evoked by upper limb rehabilitation robot training in stroke patients

Upper limb rehabilitation robot-assisted training (UE-RAT) facilitates post-stroke motor recovery. Its efficacy is evaluated using clinical scales. However, these scales mainly reflect overall motor impairment and functional performance, lacking indices to assess patients’ neurom...

Mild Mechanochemical Pretreatment of Wheat Straw for High Exergy Efficiency to Promote Efficient Enzymatic Hydrolysis and Saccharification

Abstract This study proposed a new strategy for simultaneous catalytic conversion of wheat straw with a deep eutectic solvent-assisted ball milling method at high solid content (20%) conditions, thereby improving monosaccharide yield and exergy efficiency. After mechanical sheari...

Learning chemical-induced gene expression perturbations with WAVE

Chemical-induced transcriptional profiles facilitate systematic characterization of compound-driven perturbations, offering critical insights into mechanisms of action, especially for compounds with poorly defined molecular targets. However, experimentally profiling gene expressi...

Dual‐Site Covalent Targeting Enables BD2‐Selective BET Inhibition With Potent Antitumor Activity in Mice

ABSTRACT Bromodomain and extra‐terminal (BET) proteins are validated therapeutic targets for cancer, but clinical translation of pan‐BET inhibitors is limited by dose‐limiting toxicities from non‐selective inhibition of BD1/BD2 domains. Herein, we report the first‐ever domain‐sel...

Defect-Regulated Co/CeO2 Catalysts for Selective Hydrodeoxygenation of Lignin-Derived Phenolics: Unravelling the Interfacial Hydrogenation C–O Cleavage Synergy

Lignin-derived chemicals are important renewable building blocks for a sustainable chemical industry, and their selective hydrodeoxygenation (HDO) into cyclohexanol offers a promising route to high-value products; however, efficient C–O bond cleavage over non-noble-metal catalyst...

ALDH2 inhibition reprograms tubular epithelial cell metabolism and promotes renal injury susceptibility

Fatty Acid Oxidation (FAO) dysfunction induces pro-fibrotic transition in tubular epithelial cells (TECs) and contributes to renal fibrosis in chronic kidney disease (CKD); however, the drivers of metabolic reprogramming in TECs remain unclear. We investigate the role of aldehyde...

A multicohort, biomarker-driven phase 2 trial of personalized total neoadjuvant therapy with targeted agents for high-risk rectal cancer (The TRAINER study)

This multicohort, single-center, phase II trial explored the efficacy and safety of a biomarker-driven total neoadjuvant therapy (TNT) regimen in high-risk locally advanced rectal cancer (LARC) patients. The regimen included induction chemotherapy (4 cycles of mFOLFOX6) with targ...

Crystalline Mate Assists Structural Elucidation and Offline LC‐SCXRD Analysis of Flavonoid Glycosides via Synergistic π–π Stacking and C–H···O Interactions

Single-crystal X-ray diffraction (SCXRD) is a key technique for the structural determination of organic molecules. However, natural flavonoid glycosides are difficult to crystallize due to their large volume, flexible glycosidic bonds, and limited solubility. Herein, a novel meth...

Acupoint hot compress for labor-pain management: a randomized, parallel-group, controlled trial

Background Non-pharmacological pain management approaches, including acupoint hot compress, may provide valuable support for women dealing with pain during the latent stage of labor, but the evidence supporting this effect is limited. We investigated whether acupoint hot compress...

p38β-mediated BiP phosphorylation drives stemness and chemoresistance by suppressing UPR activation in hepatocellular carcinoma

Abstract Tumor-initiating cells (TICs) promote tumor initiation and therapy resistance, yet the kinase regulators that sustain TICs remain incompletely defined. Here, we identify the stress kinase p38β (MAPK11) supports TIC maintenance and drug resistance in hepatocellular carcin...