Ministério da Saúde

Hepatitis E in suspected acute hepatitis cases in Brazil: A comparison with hepatitis A

Hepatitis E virus (HEV) is an underrecognized cause of acute viral hepatitis worldwide, with growing public health relevance, particularly in settings where routine diagnostic testing is limited. Hepatitis A virus (HAV) is another epidemiologically related hepatitis virus, but fe...

Healthcare occupancy data as an early warning indicator of infectious disease surges in São Paulo

Early detection of infectious disease surges is critical for effective public health response, yet traditional surveillance systems often suffer from delayed reporting. Here, we investigate whether passively collected occupancy data from healthcare facilities can act as an early...

A systematic review and individual patient data meta-analysis to determine the effect of primaquine dose on efficacy, tolerability and safety in uncomplicated Plasmodium vivax malaria in Latin America

Background Primaquine is widely used to prevent relapses of Plasmodium vivax malaria, but the optimal dose in Latin America is unknown. We undertook a systematic review and individual patient data meta-analysis to investigate the efficacy, tolerability and safety of different pri...