MIND Research Institute

Maternal Depression, Childhood Resting‐State Brain Connectivity, and Adolescent Depression During the COVID‐19 Outbreak

Adolescents of mothers with a history of depression are at increased risk for developing depression themselves. These adolescents may have been especially vulnerable to depression under conditions of stress, such as the beginning of the COVID-19 pandemic. To understand the comple...

Can Depression Polygenic Risk Score Predict Postinfective Fatigue Syndrome (PIFS) in the Dubbo Infection Outcomes Study (DIOS)?

Abstract Prospective cohorts show that a postinfective fatigue syndrome (PIFS) meeting criteria for chronic fatigue syndrome (CFS) develops in roughly 1 in 10 people after diverse acute infections, independent of the triggering pathogen. Whether constitutional liability to affect...

W8. HERITABILITY OF ACCELEROMETRY-DERIVED FEATURES OF PHYSICAL ACTIVITY, SLEEP AND CIRCADIAN RHYTHMICITY AND THEIR JOINT INFLUENCES IN YOUNG PEOPLE

Background Dysregulation of motor activity and sleep are key components of several mental disorders, particularly mood disorders and attention deficit hyperactivity disorder (ADHD). There is growing evidence that profiles of 24-hour activity patterns may discriminate subgroups of...

Replication of sex differences in tobacco smoking-induced dopamine responses and extension to nicotine replacement therapy

Abstract Introduction Tobacco smoking is a major public health risk, and treatment efficacy differs by sex. Previous imaging studies reported sex differences in smoking-induced striatal dopamine release, but no PET study has independently replicated these findings. We applied a n...

What one sees depends on how far the eye has moved

Humans explore visual scenes through frequent, rapid gaze shifts known as saccades. These movements redirect the high-acuity region of the retina toward objects of interest, thus selecting information based on location. Here, we show that saccade amplitude provides a separate and...

Discovery and Characterization of Inhibitors of Ubiquitin-Like Modifier Activating Enzyme 5 (UBA5): Targeting the UFMylation Pathway in Cancer and Neurodegenerative Diseases

Abstract UBA5 is the E1 enzyme that initiates UFMylation, a ubiquitin-like modification implicated in proteostasis, neurodegeneration, and cancer. Here, we report a chemical biology approach to interrogate UBA5 function through small-molecule inhibition. We developed a robust hig...