Millennium Institute on Immunology and Immunotherapy

Patient- derived gallbladder cancer organoids mirror tumor genetics and resistance phenotypes, enabling ex vivo testing of adjuvant chemotherapy response

Abstract Background Advanced gallbladder cancer (GBC) is an aggressive malignancy with poor prognosis, high recurrence rates, and limited treatment options. Patient-derived organoids (PDOs) have emerged as promising preclinical models that faithfully mimic the epithelial architec...

MHC-II+ G-MDSC expressing CD80, CD86, or ICOSL are associated with pro-inflammatory CD4+ T cells phenotypes in the lungs of lupus-prone mice

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that affects various tissues of the body. One of these tissues is the lung, in which pleuropulmonary manifestations commonly occur. In these patients, homeostasis is disrupted, characterized by a decr...