Millennium Initiative for Collaborative Research on Bacterial Resistance

Functional export of NDM-7 to outer membrane vesicles in Klebsiella pneumoniae compromises imipenem and cefiderocol activity

ABSTRACT The carbapenemases KPC and NDM are the most widespread determinants of carbapenem resistance in Klebsiella pneumoniae . Whereas KPC is a soluble periplasmic serine-β-lactamase, NDM is a membrane-anchored metallo-β-lactamase (MBL), a feature that promotes its incorporatio...