Military Medical Academy

The role of repetitive transcranial magnetic stimulation in restoration of post stroke motor power

Abstract Background Stroke causes long-term disability, and rTMS—by modulating cortical excitability and promoting neuroplasticity—may enhance post-stroke motor recovery. Aim To investigate the effect of rTMS on motor outcome in acute ischemic stroke (AIS) patients admitted withi...

Knowledge, attitudes, and practices (KAP) toward stroke prevention among hypertensive patients in Egypt: a multicenter cross-sectional study

Abstract Stroke is the second most common cause of death worldwide and represents a major health concern in Egypt. Hypertension is the most important modifiable risk factor for stroke; we aim to assess knowledge, attitudes, and practices (KAP) toward stroke prevention among hyper...

Targeted Inhibition of Intracellular Coxiella burnetii by Overcoming the Vacuolar Barrier with Autologous Exosomal Doxycycline

Abstract Coxiella burnetii, the causative agent of Q fever, is an obligate intracellular bacterium that replicates within the Coxiella-containing vacuole (CCV), a lysosome-like compartment. The acidic microenvironment within the CCV impairs the activity of weak-base antibiotics s...

Ophthalmic manifestations of trisomy 21 syndrome in the pediatric age group: a cross-sectional study from Cairo University Specialized Pediatric Hospital

Abstract Background Trisomy 21 Syndrome is one of the most common chromosomal conditions in the world, affecting an estimated 1 in 700 live births. It manifests with a wide range of ophthalmic findings. These include strabismus, amblyopia, accommodation defects, refractive error,...

In vitro studies of detoxification by intravenous fat emulsions: mechanism of action and preclinical assessment tools

Introduction The use of intravenous fat emulsions for treatment of drug intoxication still follows a trial-and-error approach, due to insufficient understanding of the mechanisms of the process and lack of predictive in vitro tools.Methods We studied the physicochemical mechanism...

Dinuclear Platinum(II)Complexes Targeting DNA andHuman Serum Albumin: Electrostatic Binding and Apoptosis-Driven AntiproliferativeActivity

Abstract Two novel dinuclear platinum(II) complexes, [{Pt(1,3-pnd)Cl}2(μ-4,4′-bipy)]Cl2 (Pt1) and [{Pt(1,3-pnd)Cl}2(μ-4,4′–SS–bipy)]Cl2 (Pt2), were synthesized and characterized by elemental analysis, UV–vis, and 1H/13C NMR spectroscopy. Spectroscopic and electrochemical studies...