Military Medical Academy

In vitro studies of detoxification by intravenous fat emulsions: mechanism of action and preclinical assessment tools

Introduction The use of intravenous fat emulsions for treatment of drug intoxication still follows a trial-and-error approach, due to insufficient understanding of the mechanisms of the process and lack of predictive in vitro tools.Methods We studied the physicochemical mechanism...

Dinuclear Platinum(II)Complexes Targeting DNA andHuman Serum Albumin: Electrostatic Binding and Apoptosis-Driven AntiproliferativeActivity

Abstract Two novel dinuclear platinum(II) complexes, [{Pt(1,3-pnd)Cl}2(μ-4,4′-bipy)]Cl2 (Pt1) and [{Pt(1,3-pnd)Cl}2(μ-4,4′–SS–bipy)]Cl2 (Pt2), were synthesized and characterized by elemental analysis, UV–vis, and 1H/13C NMR spectroscopy. Spectroscopic and electrochemical studies...