Mexican Social Security Institute

Divergent Organism-Specific Trajectories of Multidrug Resistance Across the COVID-19 Pandemic: An Interrupted Time-Series Study in a Mexican Tertiary Hospital, 2017–Early 2026

Background/Objectives: Whether the COVID-19 pandemic uniformly increased antimicrobial resistance (AMR) is contested, and aggregate analyses may mask organism-specific patterns. The objective of the study was to characterize changes in the level and slope of monthly multidrug-res...

Cleft Palate Surgery: Evolving Surgical Techniques and Reconstructive Principles for Oronasal Fistula and Velopharyngeal Dysfunction: A Narrative Review

Background Despite more than a century of surgical innovation, no single palatoplasty technique has demonstrated consistently superior outcomes across the spectrum of cleft palate phenotypes. Objective This review examines the historical evolution of cleft palate reconstruction a...

Isolated midbrain neurocysticercosis presenting as trochlear nerve palsy

Background: Neurocysticercosis (NCC) is a neurological infection caused by the larval stage of the tapeworm Taenia solium . It can be found in the brain parenchyma or in the intraventricular and subarachnoid spaces and the spinal cord, giving rise to different clinical manifestat...

Artificial Intelligence in the Diagnosis, Treatment, and Management of Rare Diseases: Opportunities and Challenges from a Latin American Perspective

Rare diseases collectively affect between 3.5 and 5.9% of the global population. Yet, patients still endure an average diagnostic interval of five to seven years before receiving an accurate explanation of their condition. Approximately 80% of these disorders have a genetic origi...

Depressive Symptom Predictors in Older Mexican Adults: Interaction Structures and Nonlinear Effects from Machine Learning Explainability

Background Depression among older adults remains a critical public health issue in Latin America, where aging populations face compounded social and health vulnerabilities. Objective To characterize psychosocial and clinical predictors of depressive symptoms among older Mexican a...

The robotic PIANO: a critical narrative review of surgeon-controlled operative polyphony, human factors, and robotic training

Abstract Robotic surgery can concentrate control of several technical functions at the console, but such concentration does not itself confer clinical independence, reduce dependence on the perioperative team, or improve patient outcomes. We define surgeon-controlled operative po...

Expanding the Clinical and Molecular Spectrum of Cartilage-Hair Hypoplasia in the Mexican Population

Cartilage-hair hypoplasia (CHH) is a rare autosomal recessive skeletal dysplasia caused by variants in RMRP (RNA component of mitochondrial RNA processing endoribonuclease), which encodes a non-coding RNA. Despite its well-established clinical and molecular spectrum in some popul...

Conservative Management of Rhinophyma with Pharmacological Therapy: Experience from a Case Report

Rhinophyma represents an advanced manifestation of phymatous rosacea and is characterized by progressive sebaceous gland hyperplasia, dermal fibrosis, and thickening of the nasal skin, resulting in cosmetic deformity and, in advanced cases, functional impairment. Although surgica...

Two Transcriptomic Analyses Converge on a Five-Gene Core for Colorectal Cancer Discrimination: External Validation in Independent Tissue Cohorts

Background/Objectives: Colorectal cancer (CRC) is a leading cause of neoplasia-related morbidity and mortality worldwide and the first cause of cancer death in Mexico, where early detection remains a challenge, and reliable molecular biomarkers could support earlier diagnosis. Tr...

High Prevalence of Fatigue is Linked to Depression in Inflammatory Bowel Disease

Fatigue is a common symptom in patients with inflammatory bowel disease (IBD). However, the prevalence is underestimated because it is not intentionally assessed during routine medical evaluation. Our study aimed to evaluate the prevalence and factors associated with fatigue in p...

CT Attenuation Thresholds for Grading Hepatic Steatosis in Adults with Overweight or Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease

Background/Objectives: To derive computed tomography (CT) attenuation thresholds for grading hepatic steatosis and evaluate their agreement with ultrasonography (US) in adults with overweight or obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) from sou...

LINAC-based stereotactic radiosurgery targeting the hippocampus in mesial temporal lobe epilepsy: a single-center case series

BACKGROUND: Epilepsy is a neurological disorder affecting over 50 million people worldwide, with a global incidence of 7.6 per 1,000 individuals. Mesial temporal lobe epilepsy (MTLE) is characterized by recurrent, unprovoked seizures originating in the temporal lobe. The standard...

Oncoplastic Reconstruction of the Anterior Chest Wall Using a Latissimus Dorsi Myocutaneous Flap: A Case Report

Background: Dermatofibrosarcoma protuberans (DFSP) is an uncommon cutaneous fibroblastic neoplasm characterized by infiltrative growth, low metastatic potential, and a high risk of local recurrence following incomplete excision. Large or recurrent tumors of the anterior chest wal...

Effects of Cention N® restorations on buccal cytogenotoxicity and salivary oxidative stress in children with dental caries

Cention N ® is an alkasite-based restorative dental material containing methacrylate monomers and ion‑releasing alkaline fillers that liberate calcium and fluoride, components that have been implicated in oxidative stress (OS) and potential DNA damage in oral epithelial tissues....

Standardized Sechium edule root extract attenuates LPS inflammation alongside transient STAT3 phosphorylation and an interleukin 10 biased macrophage response

Chronic low-grade inflammation is sustained by macrophage activation toward proinflammatory states and contributes to cardiometabolic and degenerative disorders. Given the growing interest in evidence-based medicinal plants, we investigated whether a hydroalcoholic root extract o...

How to Train Your Chatbot: Information‐Theoretic Foundations of Diagnostic Questioning in Inborn Errors of Immunity

BACKGROUND: Navigating the more than 550 inborn errors of immunity (IEI) requires efficient diagnostic reasoning. Information theory suggests questions should be prioritized by their capacity to reduce diagnostic uncertainty (entropy); yet whether experts or large language models...

A network-driven antiviral discovery pipeline for emerging RNA viruses: a critical perspective from the Red Mexicana de Desarrollo de Antivirales (RMDA)

INTRODUCTION: RNA viruses impose a disproportionate burden of emerging and reemerging infectious diseases in Latin America, yet antiviral discovery in the region remains fragmented, target-limited, and frequently disconnected from translational pathways. This perspective discusse...

Impact of Coffee Consumption on Fructose-Related Metabolic Alterations: Potential Mechanisms and Implications for Metabolic Diseases

Coffee is one of the most widely consumed beverages worldwide. Coffee and its bioactive compounds, including caffeine, chlorogenic acid, and caffeic acid, have attracted increasing attention because of their potential health benefits. Evidence from pediatric and adult populations...