MetroHealth

Biomarkers in Irritable Bowel Syndrome: Bridging Gut–Brain Mechanisms to Precision Care

Abstract Purpose of Review Irritable bowel syndrome is a common disorder of gut-brain interaction characterized by chronic abdominal pain and altered bowel habits in the absence of structural pathology. Its pathophysiology reflects a complex interplay between the central nervous...

Validation of STARZ scoring in very low birth weight (VLBW) neonates in the United States

Abstract Background Acute kidney injury (AKI) is a significant complication in very low birth weight (VLBW) neonates, associated with increased morbidity, mortality, and prolonged hospitalization. Early identification of at-risk infants enables timely interventions. The STARZ sco...

Cardiotoxicity and safety of zanubrutinib versus chemoimmunotherapy in chronic lymphocytic leukemia: a real-world retrospective cohort study using the TriNetX registry

Abstract Background Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in adults in the Western countries. Ibrutinib, a first-generation Bruton’s tyrosine kinase (BTK) inhibitor, is commonly used for relapsed/refractory CLL but is associated with cardiovascular adv...