MetroHealth

Racial-Ethnic and Sex Disparities in Mental Health Service Use Before Self-Harm Among Young People Enrolled in Medicaid

OBJECTIVE: This study examined racial-ethnic and sex differences (and their intersections) in mental health service use prior to deliberate self-harm among young people enrolled in Medicaid. METHODS: A retrospective cohort study was conducted by using Medicaid data from 25 states...

Preexisting depression and early outcomes in inflammatory bowel disease: a propensity score–matched cohort study

BACKGROUND: Depression is common in inflammatory bowel disease (IBD) and associated with adverse outcomes, but most studies examine depression arising after IBD diagnosis. Whether depression predating IBD diagnosis is independently associated with early postdiagnosis outcomes rem...

Predicting 5-Year Mortality After Prosthetic Joint Infection Using a 30-Item Accumulated Frailty Index in a 13,371-Patient Multicenter Cohort

Background Prosthetic joint infection (PJI) involves a significant mortality risk, with 26-30% of patients dying within 5 years. Current risk assessment tools offer limited prognostic accuracy for PJI patients. This study aimed to develop a prognostic model for 5-year all-cause m...

Biomarkers in Irritable Bowel Syndrome: Bridging Gut–Brain Mechanisms to Precision Care

Abstract Purpose of Review Irritable bowel syndrome is a common disorder of gut-brain interaction characterized by chronic abdominal pain and altered bowel habits in the absence of structural pathology. Its pathophysiology reflects a complex interplay between the central nervous...

Validation of STARZ scoring in very low birth weight (VLBW) neonates in the United States

Abstract Background Acute kidney injury (AKI) is a significant complication in very low birth weight (VLBW) neonates, associated with increased morbidity, mortality, and prolonged hospitalization. Early identification of at-risk infants enables timely interventions. The STARZ sco...

Cardiotoxicity and safety of zanubrutinib versus chemoimmunotherapy in chronic lymphocytic leukemia: a real-world retrospective cohort study using the TriNetX registry

Abstract Background Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in adults in the Western countries. Ibrutinib, a first-generation Bruton’s tyrosine kinase (BTK) inhibitor, is commonly used for relapsed/refractory CLL but is associated with cardiovascular adv...