Methodist University of Piracicaba

Biomechanical strain patterns in Meckel's cartilage underlie mandibular variation in FGFR2 mouse models

Abstract Sequence variations in fibroblast growth factor receptor 2 (FGFR2) are associated with craniosynostosis syndromes, disrupting craniofacial development, yet early mandibular alterations remain poorly characterized. This study examined Meckel's cartilage (MC) and mandibula...

Can vision-language models estimate patient age? evidence from panoramic radiographs

Abstract Objective To explore the performance and limitations of three vision-language models (VLMs) in estimating chronological age from panoramic radiographs. Materials and Methods A sample of 140 panoramic radiographs from individuals aged 7 to 20 years was uploaded to three V...

Data-Driven Framework Integrating Database Analysis and Bayesian Segmented Quantile Regression to Determine Critical Nutrient Levels in Soil and Leaves of Peach Trees

Fertilization recommendations are frequently proposed by a limited number of calibration experiments conducted in a few regions, with few cultivars. Thus, recommendations concerning nutrients’ critical levels (CLs) and sufficiency ranges (SRs) are not always the most suitable one...

Effect of a sodium fluoride rinse on the composition of early oral biofilms formed in situ on enamel and dentine

OBJECTIVES: Dental caries results from dysbiotic shifts in the microbial community, so modulating biofilm composition represents a valid preventive strategy. The aim of this double-blind randomized crossover in situ study was to investigate how a fluoride rinse can modify the com...

Structurally conditioned autonomy and assisted dying: health equity, vulnerability, and end-of-life decision-making

Assisted dying is frequently justified through appeals to individual autonomy and self-determination. However, contemporary end-of-life decision-making occurs within broader social, economic, and institutional conditions that may significantly shape experiences of suffering and t...

Coffea Comparative Genomics Reveals Subgenome-Associated Expansion and Diversification of Biosynthetic Gene Clusters

Biosynthetic gene clusters (BGCs) are important for plant specialized metabolism, but remain poorly characterized in coffee. Given Brazil’s importance in coffee production, we performed a comparative genomic analysis of BGCs across the allotetraploid Coffea arabica and its diploi...

Effects of organic solvents on the depth‐of‐cure determination of conventional and bulk‐fill resin composites

This study investigated the influence of organic solvents on the depth of cure (DOC) of resin composites. Two conventional (Filtek Universal [FU] and Beautifil II [BE]) and two bulk-fill (Filtek One Bulk Fill [FO] and Beautifil-Bulk [BB]) composites were evaluated. Cylindrical sp...

Smart Coatings Integrating Antimicrobial and Tissue‐Remodeling Functions for Implant Interfaces

AIM: This study aimed to assess the antimicrobial performance and biocompatibility of our drug delivery platform, based on layer-by-layer (LbL) coating incorporating tetracycline (TC) complexed with anionic β-cyclodextrin (TCβCD) and a pH-responsive poly(methacrylic acid) (PMAA)...

Genome-wide analysis of lipoxygenase genes in Coffea arabica and its diploid progenitors

Lipoxygenase proteins (LOXs) play a crucial role in plant growth, development, and defense notably through their involvement in jasmonic acid (JA) biosynthesis. Here, we aimed to identify and characterize genes encoding lipoxygenases in three coffee species, Coffea arabica, Coffe...