Methodist Hospital

Real-World Versus Centers for Medicare and Medicaid Services Estimates of Pediatric Retinal Detachment Repair Times

Purpose: To compare real-world pediatric retinal detachment (RD) repair times with the Centers for Medicare and Medicaid Services (CMS) estimates for complex RD surgeries. Methods: A cross-sectional survey was performed of complex pediatric RD perioperative times from pediatric r...

Endoscopic Retrograde Cholangiopancreatography in Pediatric Pancreas Divisum: Systematic Review

Background: Pancreas divisum (PD) may be associated with recurrent acute pancreatitis (RAP) or chronic pancreatitis (CP), but data on ERCP outcomes in children with PD are limited. We conducted a systematic review of the clinical, technical, and safety outcomes of ERCP for PD in...

Vasoconstrictor therapy for HRS-AKI in patients listed for liver transplantation: Translating evidence to the pretransplant setting

Hepatorenal syndrome-acute kidney injury (HRS-AKI) is a life-threatening complication of decompensated cirrhosis and carries significant implications for liver transplantation (LT) candidacy and outcomes. Terlipressin, a synthetic vasopressin analogue, has emerged as a first-line...

A multicenter multistate modeling on the natural history of liver decompensation: Longitudinal analysis of 1777 patients.

BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced chronic liver disease (cAC...

Surgical Management of Lacrimal Gland Tumors

Epithelial lacrimal gland tumors are rare but important to diagnose early. The initial surgical decision to do an incisional biopsy versus gross total resection depends largely on the radiologic characteristics of the lacrimal gland mass. Until recently, orbital exenteration was...

Comparative adjuvant therapy to reduce vancomycin-associated nephrotoxicity in an animal model

Vancomycin is a mainstay antibiotic for serious gram-positive infections, but nephrotoxicity remains a major barrier to its optimal use. In this study, we compared the effectiveness of montelukast and zileuton as adjuvant strategies to reduce vancomycin-associated nephrotoxicity....

Clinical and Radiologic Features Correlated with Eye-Sparing Surgery vs. Orbital Exenteration for Lacrimal Gland Adenoid Cystic Carcinoma

Background: To determine if certain clinical and radiologic features of lacrimal gland adenoid cystic carcinoma (LGACC) on pre-operative MRI were associated with the treatment decision to perform orbital exenteration versus eye-sparing surgery. Methods: All consecutive patients w...

Combination GLP-1RA and Low-Dose IL-2 Modulates Peripheral Immune Activation and Attenuates CNS Inflammatory Transcript Signatures In Vivo

Immune dysregulation characterized by persistent myeloid activation and associated impairment of regulatory T cell (Treg) function contributes to inflammatory signaling across peripheral and central compartments in neurodegenerative diseases. We evaluated whether combining a gluc...

Alcohol Use Severity Among Hispanic Emerging Adult College Students: Examining Acculturation Stress, Self-Esteem, and Resilience in a Stress and Coping Framework

Research on acculturation stress and its effects on alcohol-related outcomes among Hispanics has been the subject of many studies. However, these studies are limited because they generally use a single measure of acculturation stress to account for this complex construct, and mos...

sGC oxidation impairs NO-dependent ophthalmic artery vascular reactivity and alters long-term memory performance in mice

Nitric oxide (NO)-dependent activation of soluble guanylyl cyclase (sGC) is essential for maintaining cerebrovascular function and cognitive processes. However, sGC is susceptible to oxidative inactivation under vascular and neurodegenerative stress. This study investigated the i...

Rhinosinusitis in Adults Receiving Tumor Necrosis Factor Alpha Inhibitors and Anti‐CD20 Therapy: A Scoping Review

ABSTRACT Introduction Immunomodulatory therapies, including tumor necrosis factor alpha (TNF‐α) inhibitors and anti‐CD20 agents, are often used for autoimmune, inflammatory, and neoplastic disorders. While infection risk is well recognized, their association with rhinosinusitis r...

Shared CI-linked bioenergetic dysfunction and muscle-specific lipid/redox stress in skeletal muscle of male cardiometabolic HFpEF mice

Exercise intolerance is a hallmark of heart failure with preserved ejection fraction (HFpEF), particularly in its cardiometabolic form, where obesity, metabolic dysfunction, and impaired peripheral oxygen utilization contribute to functional limitation. Skeletal muscle mitochondr...

Idylla™ POLE-POLD1 mutation assay for molecular characterization and risk stratification of endometrial cancers: a retrospective multicenter validation study

Endometrial carcinoma (EC) is a common gynecological cancer with rising incidence driven by obesity and aging populations. Accurate and timely molecular classification is critical for guiding personalized oncology treatment, especially in early-stage high-grade endometrioid carci...

Identification of SKI-II as a host-protective immunomodulator against Staphylococcus aureus infection

ABSTRACT Antibiotic resistance threatens the effectiveness of conventional antimicrobial agents, underscoring the need for host-directed therapies that enhance immune defense. Here, we present a cross-species discovery pipeline that couples a Caenorhabditis elegans–Staphylococcus...

Autoimmune diseases involving the gastrointestinal tract: clinical patterns, imaging spectrum, and complications

Autoimmune diseases frequently involve the gastrointestinal (GI) tract and can present with nonspecific symptoms that delay diagnosis. Their manifestations range from subtle motility disturbances to life-threatening ischemia, perforation, or obstruction. Advances in cross-section...

Intraprocedural cardiac computed tomography-fluoroscopy image fusion guided structural heart intervention: a proof of concept experience during transcatheter aortic valve implantation

Intraoperative image guidance using cardiac CT with fluoroscopy image fusion has been shown to facilitate structural heart interventions. However, there has been limited experience on CT image fusion with fluoroscopy using aortic root calcifications from intraoperative 3D cone-be...

Spatially defined IGF1R-STMN1 axis delineates a metastatic cell state in osteosarcoma

Abstract Metastatic osteosarcoma (OS) remains the leading cause of disease-related mortality, yet effective therapies are still lacking. Here, we integrated single-cell RNA sequencing, spatial transcriptomics, and functional assays to investigate signaling dependencies in OS meta...