Methodist Hospital

Idylla™ POLE-POLD1 mutation assay for molecular characterization and risk stratification of endometrial cancers: a retrospective multicenter validation study

Endometrial carcinoma (EC) is a common gynecological cancer with rising incidence driven by obesity and aging populations. Accurate and timely molecular classification is critical for guiding personalized oncology treatment, especially in early-stage high-grade endometrioid carci...

Identification of SKI-II as a host-protective immunomodulator against Staphylococcus aureus infection

ABSTRACT Antibiotic resistance threatens the effectiveness of conventional antimicrobial agents, underscoring the need for host-directed therapies that enhance immune defense. Here, we present a cross-species discovery pipeline that couples a Caenorhabditis elegans–Staphylococcus...

Autoimmune diseases involving the gastrointestinal tract: clinical patterns, imaging spectrum, and complications

Autoimmune diseases frequently involve the gastrointestinal (GI) tract and can present with nonspecific symptoms that delay diagnosis. Their manifestations range from subtle motility disturbances to life-threatening ischemia, perforation, or obstruction. Advances in cross-section...

Intraprocedural cardiac computed tomography-fluoroscopy image fusion guided structural heart intervention: a proof of concept experience during transcatheter aortic valve implantation

Intraoperative image guidance using cardiac CT with fluoroscopy image fusion has been shown to facilitate structural heart interventions. However, there has been limited experience on CT image fusion with fluoroscopy using aortic root calcifications from intraoperative 3D cone-be...

Spatially defined IGF1R-STMN1 axis delineates a metastatic cell state in osteosarcoma

Abstract Metastatic osteosarcoma (OS) remains the leading cause of disease-related mortality, yet effective therapies are still lacking. Here, we integrated single-cell RNA sequencing, spatial transcriptomics, and functional assays to investigate signaling dependencies in OS meta...