Merck Serono S.p.A. (Italy)

Language of Toxicity: An eXplainable Artificial Intelligence Approach

Abstract Toxicity prediction in small molecules represents a fundamental challenge in drug development and chemical safety assessment. Traditional approaches heavily rely on predefined molecular descriptors or fingerprints, potentially limiting the ability to capture complex and...

Antibody framework engineering enables augmented cytokine receptor signaling capacities of bispecific single domain antibody-based IL-21 mimetics

In this work, we developed bispecific antibody (bsAb)-derived surrogate agonists which mimic the function of IL-21 by targeting the IL-21 receptor composed of IL-21 R (CD360) and IL-2 Rγ (CD132). For this, antigen-specific VHHs (variable domains of the heavy chain of heavy-chain-...

Characterization of Full‐Length Antibody Complexes Through HDX‐Mass Spectrometry Coupled With NMR Spectroscopy: New Insight Into Avelumab/PD‐L1 Interaction

ABSTRACT Recombinant biomacromolecules have significantly transformed pharmaceuticals, in particular monoclonal antibodies (mAbs) that target key areas in oncology, immunology, inflammation, and neurodegenerative diseases. Developing biotherapeutics requires a detailed understand...

Acoustic Vases in Europe: A Review of Documentation, Approaches, Measurement Methodologies, and Preliminary Proposal for a Methodological Framework

Research on acoustic vases embedded in historical buildings has progressively developed through archaeology, architectural history, and acoustics, producing extensive documentation on their distribution, geometry, installation and possible acoustic role, with experimental evidenc...