Merck & Co., Inc., Rahway, NJ, USA (United States)

A new standard for lyophilizer characterization, comparability and efficient technology transfers

This paper details the implementation of the ΔT and ΔP methodologies—recently introduced in the literature—for monitoring of mass flow during sublimation, demonstrating their application across multiple pharmaceutical companies. As a relatively new approach, this work is assessin...

Trends in vaccination in pharmacy and medical settings among Medicaid recipients in the United States, 2018–2023: a claims analysis

BACKGROUND: Medicaid beneficiaries typically have low vaccination rates, in part due to limited access. Pharmacies provide easy-to-access locations for vaccination. RESEARCH DESIGN AND METHODS: This was a retrospective analysis of trends in pharmacy-based vaccination by age and r...

Wnt Pathway Agonism as a Therapeutic Strategy for Retinal Vascular Diseases: A Narrative Review of Evidence to Date

Breakdown of the blood–retinal barrier (BRB) is implicated in many blinding retinal diseases, including diabetic macular edema, neovascular age-related macular degeneration, and retinal vein occlusion. Anti-vascular endothelial growth factor (anti-VEGF) therapies or laser photoco...

Cost-effectiveness of pembrolizumab as neoadjuvant therapy and in combination with standard of care (SOC) as adjuvant therapy for stage III-IVA resectable locally advanced head and neck squamous cell carcinoma (LA HNSCC) in Switzerland

AIMS: KEYNOTE-689 trial results demonstrated that neoadjuvant pembrolizumab followed by adjuvant pembrolizumab plus standard of care (NP/AP + SOC) significantly improved event-free survival (EFS) versus SOC alone in patients with locoregionally advanced head and neck squamous cel...

Invasive pneumococcal disease in Latin America: serotype distribution and vaccine coverage among adults in Mexico, Brazil, and Argentina

BACKGROUND: Invasive pneumococcal disease (IPD) causes substantial morbidity and mortality among adults in Latin America. Despite high pediatric pneumococcal conjugate vaccine (PCV), uptake, adult coverage remains low, and residual IPD burden persists. Among currently available P...