Mengchao Hepatobiliary Hospital

Integrated expression and network-based characterization of H19-associated molecular alterations in Metabolic Dysfunction-Associated Fatty Liver Disease

Metabolic dysfunction-associated fatty liver disease (MAFLD) is characterized by hepatic lipid accumulation and metabolic dysregulation. However, reproducible noncoding RNA-associated molecular alterations in human liver tissue remain incompletely defined. We aimed to characteriz...

Solvent-Engineered Fe-Doped CuCo Prussian Blue Analogue Nanozyme with Enhanced Catalytic Activity for Dual-Mode Colorimetric and Electrochemical Immunoassays

Abstract Early and accurate determination of human epidermal growth factor receptor 2 (HER2) is of great significance for the diagnosis and prognosis evaluation of breast cancer. Herein, a structurally transformed Fe-doped hexagon-like CuCo Prussian blue analogue (FeCuCoPBAH) wit...

A CCCTC-binding factor (CTCF)-fatty acid desaturase 1 (FADS1) axis regulates oncogenic energy metabolism in hepatocellular carcinoma

CCCTC-binding factor (CTCF) is a highly conserved DNA-binding protein crucial for 3D genome organization and gene regulation. Previous studies have shown that CTCF overexpression in hepatocellular carcinoma (HCC) is associated with poor prognosis. This study aimed to elucidate th...

Integrative transcriptomic and single-cell analysis identifies anoikis-related molecular signatures in vascular calcification

BACKGROUND: Vascular calcification (VC) is a life-threatening complication of chronic kidney disease (CKD) driven by vascular smooth muscle cell (VSMC) osteogenic transdifferentiation. Anoikis, a form of adhesion-dependent apoptosis, is involved in cardiovascular remodeling, yet...