Memorial Sisli Hospital

Composite Uric Acid Index for Prediction of Significant Coronary Stenosis on Computed Tomography Angiography

OBJECTIVE: A recently proposed uric acid index combining fasting glucose, triglycerides, and uric acid has shown promise in cardiovascular risk stratification. It was assessed whether the index could predict significant coronary artery stenosis (≥50%) on coronary computed tomogra...

The new WHO infertility guideline: A universal right to equitable, evidence‐based fertility care

Abstract The WHO ‘Guideline for the prevention, diagnosis and treatment of infertility’ heralds a significant global shift towards recognizing infertility as a medical condition requiring prevention, diagnosis, treatment and policy support. This recognition is vital for the one i...

Early Lean Tissue Loss and Nutritional Challenges Following Sleeve Gastrectomy in a Kidney Transplant Recipient: A Case Report

Background/Objectives: Obesity after kidney transplantation impairs graft function, but the time course of lean tissue loss after sleeve gastrectomy in this population is poorly described. Methods: A 46-year-old woman underwent sleeve gastrectomy five years after kidney transplan...

Early mRNA expression of pro-inflammatory cytokines and ADAMTS-5 in an acute ischemia/reperfusion–induced pressure ulcer model, a pilot exploratory animal study

Objectives: This study aimed to determine the messenger ribonucleic acid (mRNA) expression levels of interleukin (IL)-1α, IL-1β, IL-6, IL-17, and A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) -5 in an acute ischemia/reperfusion (I/R)-induced pressure ulc...

Blood Pressure and Angina-Related Health Status During Benidipine Therapy: A Multicenter Real-World Cohort Study

Background: Benidipine is a long-acting calcium channel blocker used for the treatment of hypertension and chronic coronary syndrome. Although it effectively lowers blood pressure (BP), the relationship between BP reduction and improvement in angina-related health status during b...

Impact of adjuvant endocrine therapy on disease-free survival in early triple-positive breast cancer: a multicenter retrospective cohort study of the Turkish oncology group

Triple-positive breast cancer (TPBC), characterized by concurrent ER, PR, and HER2 positivity, poses unique therapeutic challenges due to ER–HER2 crosstalk. The optimal adjuvant endocrine therapy in TPBC patients receiving anti-HER2 regimens remains poorly defined. This multicent...